Reply to 'Mechanisms of ryanodine receptor 2 dysfunction in heart failure'

Affiliations

¹ Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
² The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.
³ Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. arm42@cumc.columbia.edu.

Comment

Haikel Dridi et al. Nat Rev Cardiol. 2020 Nov.

. 2020 Nov;17(11):749-750.

doi: 10.1038/s41569-020-00444-w.

¹ Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
² The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.
³ Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. arm42@cumc.columbia.edu.

No abstract available

Comment on

Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target.
Dridi H, Kushnir A, Zalk R, Yuan Q, Melville Z, Marks AR. Dridi H, et al. Nat Rev Cardiol. 2020 Nov;17(11):732-747. doi: 10.1038/s41569-020-0394-8. Epub 2020 Jun 18. Nat Rev Cardiol. 2020. PMID: 32555383 Free PMC article. Review.
Mechanisms of ryanodine receptor 2 dysfunction in heart failure.
Alvarado FJ, Valdivia HH. Alvarado FJ, et al. Nat Rev Cardiol. 2020 Nov;17(11):748. doi: 10.1038/s41569-020-00443-x. Nat Rev Cardiol. 2020. PMID: 32901150 No abstract available.

1. Alvarado, F. J. & Valdivia, H. H. Mechanisms of ryanodine receptor 2 dysfunction in heart failure. Nat. Rev. Cardiol. https://doi.org/10.1038/s41569-020-00443-x (2020).
1. Dridi, H. et al. Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target. Nat. Rev. Cardiol. https://doi.org/10.1038/s41569-020-0394-8 (2020). - DOI - PubMed
1. Marx, S. O. et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101, 365–376 (2000). - DOI
1. Kushnir, A., Shan, J., Betzenhauser, M. J., Reiken, S. & Marks, A. R. Role of CaMKIIδ phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc. Natl Acad. Sci. USA 107, 10274–10279 (2010). - DOI
1. Wehrens, X. H., Lehnart, S. E., Reiken, S. R. & Marks, A. R. Ca²⁺/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ. Res. 94, 61–70 (2004). - DOI