Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Nov;17(11):748.
doi: 10.1038/s41569-020-00443-x.

Mechanisms of ryanodine receptor 2 dysfunction in heart failure

Francisco J Alvarado  1 , Héctor H Valdivia  2
Affiliations
Comment

Mechanisms of ryanodine receptor 2 dysfunction in heart failure

Francisco J Alvarado et al. Nat Rev Cardiol. 2020 Nov.
No abstract available

PubMed Disclaimer

Comment in

Comment on

References

    1. Dridi, H. et al. Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target. Nat. Rev. Cardiol. https://doi.org/10.1038/s41569-020-0394-8 (2020). - DOI - PubMed
    1. Kushnir, A., Wajsberg, B. & Marks, A. R. Ryanodine receptor dysfunction in human disorders. Biochim. Biophys. Acta Mol. Cell Res. 1865, 1687–1697 (2018). - DOI
    1. Wehrens, X. H. et al. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc. Natl Acad. Sci. USA 103, 511–518 (2006). - DOI
    1. Xiao, B. et al. Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts. Biochem. J. 396, 7–16 (2006). - DOI
    1. Zhang, Y. et al. Cardiomyocyte PKA ablation enhances basal contractility while eliminates cardiac β-adrenergic response without adverse effects on the heart. Circ. Res. 124, 1760–1777 (2019). - DOI

Substances

LinkOut - more resources