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Review
. 2022 Oct;29(10):1084-1093.
doi: 10.1002/jhbp.826. Epub 2020 Oct 4.

Cholangiocyte derived carcinomas and local microbiota

Ariel A Arteta  1   2   3 , Martha Milanes-Yearsley  4   5 , Nora Cardona-Castro  6
Affiliations
Review

Cholangiocyte derived carcinomas and local microbiota

Ariel A Arteta et al. J Hepatobiliary Pancreat Sci. 2022 Oct.

Abstract

Trillions of bacteria are present in the gastrointestinal tract as part of the local microbiota. Bacteria have been associated with a wide range of gastrointestinal diseases including malignant neoplasms. The association of bacteria in gastrointestinal and biliary tract carcinogenesis is supported in the paradigm of Helicobacter pylori and intestinal-type gastric cancer. However, the association of bacterial species to a specific carcinoma, different from intestinal-type gastric cancer is unresolved. The relationship of bacteria to a specific malignant neoplasm can drive clinical interventions. We review the classic bacteria risk factors identified using cultures and PCR (polymerase chain reaction) with new research regarding a microbiota approach through 16S rRNA (16S ribosomal ribonucleic acid gene) or metagenomic analysis for selected carcinomas in the biliary tract.

Keywords: biliary tract1; extrahepatic cholangiocarcinoma5; gallbladder4; microbiota2; pancreas3.

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References

    1. Bridgewater JA, Goodman KA, Kalyan A, Mulcahy MF. Biliary tract cancer: epidemiology, radiotherapy, and molecular profiling. Am Soc Clin Oncol Educ Book 2016;35:e194-e203.
    1. Luchini C, Capelli P, Scarpa A. Pancreatic ductal adenocarcinoma and its variants. Surg Pathol Clin. 2016;9(4):547-60.
    1. Keplinger KM, Bloomston M. Anatomy and embryology of the biliary tract. Surg Clin North Am. 2014;94(2):203-17.
    1. Noë M, Brosens LAA. Pathology of pancreatic cancer precursor lesions. Surg Pathol Clin. 2016;9(4):561-80.
    1. Liou G-Y, Bastea L, Fleming A, Döppler H, Edenfield BH, Dawson DW, et al. The presence of interleukin-13 at pancreatic ADM/PanIN lesions alters macrophage populations and mediates pancreatic tumorigenesis. Cell Rep. 2017;19(7):1322-33.

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