Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2021 Feb;33(2):e13971.
doi: 10.1111/nmo.13971. Epub 2020 Sep 9.

Comparison of longitudinal and radial characteristics of intra-anal pressures using 3D high-definition anorectal manometry between children with anoretal malformations and functional constipation

Lusine Ambartsumyan  1 , Michele Shaffer  2 , Kristen Carlin  3 , Samuel Nurko  4
Affiliations
Comparative Study

Comparison of longitudinal and radial characteristics of intra-anal pressures using 3D high-definition anorectal manometry between children with anoretal malformations and functional constipation

Lusine Ambartsumyan et al. Neurogastroenterol Motil. 2021 Feb.

Abstract

Background: Pathophysiology of fecal incontinence (FI) in children with anorectal malformations (AM) is not well understood. Standard or high-resolution anorectal manometry (ARM) does not identify radial asymmetry or localize abnormal sphincter function. 3D high-definition anorectal manometry (HDARM) provides detailed topographic and 3D pressure gradient representation of anal canal.

Aims: To compare intra-anal pressure profiles between children with AM and controls using HDARM and to determine the association between manometric properties and reported predictors of fecal continence (AM type, spinal anomaly, and sacral integrity).

Methods: HDARM tracings of 30 children with AM and FI referred for ARM were compared with 30 age and sex-matched children with constipation. 2D pressure profiles were used to measure length of high-pressure zone (HPZ). Longitudinal and radial measurements of sphincter pressure at rest and squeeze were taken along each segment in 3D topographic views and compared between groups.

Key results: 3D measurements demonstrated longitudinal and radial differences between groups along all quadrants of HPZ. At rest, intra-anal pressures were lower along the four segments longitudinally across the anal canal and radially along the quadrants in AM group (P < .01). At squeeze, all quadrant pressures were lower in segments 1-4 in AM group (P < .01). Sensation was abnormal in AM group (P < .01). Intra-anal pressures longitudinally and radially were not associated with predictors of fecal continence.

Conclusions and inferences: Children with AM had abnormal sensation and lower pressures longitudinally and radially along all quadrants of anal canal. Manometric properties at rest were not associated with reported predictors of fecal continence.

Keywords: Anorectal manometry; anorectal malformation; children; constipation; fecal incontinence; high-definition anorectal manometry.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

REFERENCES

    1. Kim HL, Gow KW, Penner JG, Blair GK, Murphy JJ, Webber EM. Presentation of low anorectal malformations beyond the neonatal period. Pediatrics. 2000;105(5):E68.
    1. Masi P, Miele E, Staiano A. Pediatric anorectal disorders. Gastroenterol Clin North Am. 2008;37(3):709-730, x.
    1. Turowski C, Dingemann J, Gillick J. Delayed diagnosis of imperforate anus: an unacceptable morbidity. Pediatr Surg Int. 2010;26(11):1083-1086.
    1. Bischoff A, Levitt MA, Pena A. Bowel management for the treatment of pediatric fecal incontinence. Pediatr Surg Int. 2009;25(12):1027-1042.
    1. Levitt M, Pena A. Update on pediatric faecal incontinence. Eur J Pediatr Surg. 2009;19(1):1-9.

Publication types

LinkOut - more resources