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. 2020 Aug 12:12:213.
doi: 10.3389/fnagi.2020.00213. eCollection 2020.

Gray Matter Alterations in Parkinson's Disease With Rapid Eye Movement Sleep Behavior Disorder: A Meta-Analysis of Voxel-Based Morphometry Studies

Chengxian Yang  1 , Jianbo Chang  1 , Xiaohang Liang  2 , Xinjie Bao  1 , Renzhi Wang  1
Affiliations

Gray Matter Alterations in Parkinson's Disease With Rapid Eye Movement Sleep Behavior Disorder: A Meta-Analysis of Voxel-Based Morphometry Studies

Chengxian Yang et al. Front Aging Neurosci. .

Abstract

Background: Gray matter (GM) alterations in Parkinson's disease (PD) patients with rapid eye movement sleep behavior disorder (RBD) have been demonstrated in many neuroimaging studies using voxel-based morphometry (VBM). However, the inconsistent findings between studies cannot be applied to clinical practice as a neuroimaging biomarker. We performed a meta-analysis of VBM studies at a whole-brain level to investigate GM differences between PD patients with and without RBD. Methods: A systematic search was conducted in PubMed, Embase, and Web of Science from inception to November 2019 to identify eligible VBM studies. We adopted the latest Seed-based d Mapping with Permutation of Subject Images technique to quantitatively estimate the difference of regional GM volume between PD patients with and without RBD. Results: We included five studies comprising 105 PD patients with RBD and 140 PD patients without RBD. The pooled meta-analysis revealed that PD patients with RBD showed a significant reduction of GM volume in the right superior temporal gyrus (STG) compared with those without RBD. This result was confirmed to be robust by the jackknife sensitivity analysis. Conclusion: Our finding shows significantly and robustly reduced GM volume in the right STG in PD patients with RBD, preliminarily suggesting the association of GM atrophy in this brain region with the occurrence of RBD in PD patients.

Keywords: Parkinson's disease; gray matter; neuroimaging; sleep disorder; voxel-based morphometry.

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Figures

Figure 1
Figure 1
Flow diagram illustrating the results of the study selection and inclusion in the current meta-analysis.
Figure 2
Figure 2
Decreased (red) GM volume in PD patients with RBD compared with those without RBD.
Figure 3
Figure 3
Results of funnel plot analysis to test for publication bias.
See this image and copyright information in PMC

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References

    1. Albajes-Eizagirre A., Solanes A., Fullana M. A., Ioannidis J. P. A., Fusar-Poli P., Torrent C., et al. . (2019a). Meta-analysis of voxel-based neuroimaging studies using seed-based d mapping with permutation of subject images (SDM-PSI). J. Vis. Exp. 153:841. 10.3791/59841 - DOI - PubMed
    1. Albajes-Eizagirre A., Solanes A., Vieta E., Radua J. (2019b). Voxel-based meta-analysis via permutation of subject images (PSI): theory and implementation for SDM. NeuroImage 186, 174–184. 10.1016/j.neuroimage.2018.10.077 - DOI - PubMed
    1. Ansari M., Rahmani F., Dolatshahi M., Pooyan A., Aarabi M. H. (2017). Brain pathway differences between Parkinson's disease patients with and without REM sleep behavior disorder. Sleep Breath 21, 155–161. 10.1007/s11325-016-1435-8 - DOI - PubMed
    1. Baiano M., David A., Versace A., Churchill R., Balestrieri M., Brambilla P. (2007). Anterior cingulate volumes in schizophrenia: a systematic review and a meta-analysis of MRI studies. Schizophr Res 93, 1–12. 10.1016/j.schres.2007.02.012 - DOI - PubMed
    1. Barber T. R., Klein J. C., Mackay C. E., Hu M. T. M. (2017). Neuroimaging in pre-motor Parkinson's disease. Neuroimage Clin. 15, 215–227. 10.1016/j.nicl.2017.04.011 - DOI - PMC - PubMed

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