Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jun 1;167(6):1945-50.
doi: 10.1084/jem.167.6.1945.

Passive acquired mucosal immunity to group A streptococci by secretory immunoglobulin A

D Bessen  1 , V A Fischetti
Affiliations

Passive acquired mucosal immunity to group A streptococci by secretory immunoglobulin A

D Bessen et al. J Exp Med. .

Abstract

We present a model in which animals are passively immunized at a mucosal site, allowing one to evaluate immunological protection at the mucosal level only. Affinity-purified, anti-M protein sIgA administered intranasally protected mice against systemic infection after intranasal challenge with group A streptococci. In contrast, anti-M protein serum Ig administered intranasally was not protective at this site, although it neutralized the antiphagocytic property of M protein and promoted phagocytosis. Protection by sIgA occurred despite the lower immunoreactivity of sIgA to purified M protein compared with serum Ig. The data suggest that sIgA can protect at the mucosa and may preclude the need for opsonic IgG in preventing streptococcal infection.

PubMed Disclaimer

References

    1. Acta Pathol Microbiol Immunol Scand B. 1985 Dec;93(6):401-5 - PubMed
    1. J Exp Med. 1959 Aug 1;110(2):271-92 - PubMed
    1. J Immunol. 1983 Feb;130(2):896-902 - PubMed
    1. J Clin Invest. 1973 Aug;52(8):1885-92 - PubMed
    1. J Exp Med. 1985 Mar 1;161(3):623-8 - PubMed

Publication types

MeSH terms

Substances