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Review
. 2020 Aug 20:14:2383-2395.
doi: 10.2147/OPTH.S262085. eCollection 2020.

Analysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review

Harrish Nithianandan  1 , Ajay E Kuriyan  2 , Michael J Venincasa  3 , Jayanth Sridhar  3
Affiliations
Review

Analysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review

Harrish Nithianandan et al. Clin Ophthalmol. .

Abstract

Purpose: This systematic review examined the relationship between industry funding and the presence of spin in high-impact studies evaluating intravitreal corticosteroid therapy for diabetic macular edema.

Methods: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. MEDLINE and Embase were systematically searched from inception through July 16, 2018, for randomized controlled trials and meta-analyses investigating the treatment of patients with diabetic macular edema using intravitreal corticosteroid therapy. Only studies published in English journals with an impact factor greater than 2 as per the Clarivate Analytics 2017 Journal Citation Report were included. The authors independently assessed study quality, funding source and the presence of reporting bias using a standardized datasheet.

Results: Title and abstract screening were completed on 7158 unique hits and full-text review yielded 44 included studies. Overall, there was correspondence between the wording of abstract conclusions and study results in 41/44 (93%) articles. Correspondence between abstract conclusions and significance of main outcome was present in 14/14 (100%) industry-funded and 27/30 (90%) nonindustry-funded studies. The odds ratio of industry funding being associated with noncorrespondence was 0.27 (95% CI: 0.01-5.61, p=0.54). The most common reason for noncorrespondence was the failure to mention rates of steroid-related intraocular pressure elevation.

Conclusion: The results of this systematic review indicate that biased abstract outcome reporting is rare in published randomized controlled trials and meta-analyses of intravitreal corticosteroid therapy for diabetic macular edema. Biased reporting was not associated with the presence of industry funding or a conflict of interest.

Keywords: corticosteroids; diabetic retinopathy; intravitreal therapy; macular edema; systematic review.

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Conflict of interest statement

JS is a consultant for Alcon Laboratories, Alimera Science, Oxurion, Regeneron, and Thrombogenics. AEK is a consultant for Allergan, Alimera Sciences, Regeneron, and Valeant and receives grant funding from Bausch Health, Roche/Genentech and Second Sight. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Selection of randomized clinical trials and meta-analyses.
See this image and copyright information in PMC

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