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. 2020 Jun 27;9(4):217-220.
doi: 10.1007/s13691-020-00428-0. eCollection 2020 Oct.

Prostate-specific antigen (PSA) bounce following salvage radiotherapy to the prostate bed in a patient with prostate cancer post-prostatectomy

Michael Rowe  1 , Ellis Adamson  1 , John McGrane  1
Affiliations

Prostate-specific antigen (PSA) bounce following salvage radiotherapy to the prostate bed in a patient with prostate cancer post-prostatectomy

Michael Rowe et al. Int Cancer Conf J. .

Abstract

We present a case of prostate-specific antigen (PSA) bounce in a 76 year old man who underwent salvage radiotherapy to the prostate bed following biochemical relapse 6 years post-radical prostatectomy for a T2N0 Gleason grade 3 + 3 prostate adenocarcinoma; 10 months following completion of salvage radiotherapy for biochemical PSA recurrence of 0.2 μg/L. Following undetectable results (<0.03 μg/L), his PSA rose from 0.04 to 0.3 μg/L with no evidence of prostate cancer recurrence before returning to undetectable levels without medical intervention. This PSA 'bounce phenomenon' is well described following radiotherapy to an intact prostate and has been proposed to be the result of a late fibrotic effect on irradiated prostate tissue. To our knowledge, this is the first case published describing the effect in the post-prostatectomy setting. It highlights the importance of serial PSA monitoring to confirm biochemical relapse before committing the patient to androgen deprivation therapy (with its inherent risks and side effects).

Keywords: PSA bounce; Prostate cancer; Radiotherapy.

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Conflict of interest statement

Conflict of interestThe authors have no conflicts of interest to declare for this manuscript.

Figures

Fig. 1
Fig. 1
PSA trend over time. PSA reading of 0 represents “undetectable values” (<0.03 μg/L)
Fig. 2
Fig. 2
Prostate bed radiotherapy plan isodoses
See this image and copyright information in PMC

References

    1. Sheinbein C, Teh BS, Mai WY, et al. Prostate-specific antigen bounce after intensity-modulated radiotherapy for prostate cancer. Urology. 2010;76:728–733. doi: 10.1016/j.urology.2009.04.074. - DOI - PubMed
    1. Caloglu M, Ciezki JP, Reddy CA, et al. PSA bounce and biochemical failure after brachytherapy for prostate cancer: a study of 820 patients with a minimum of 3 years of follow-up. Int J Radiat Oncol Biol Phys. 2011;80(3):735–741. doi: 10.1016/j.ijrobp.2010.02.021. - DOI - PubMed
    1. Akyol F, Ozyigit G, Selek U, et al. PSA bouncing after short term androgen deprivation and 3D-conformal radiotherapy for localized prostate adenocarcinoma and the relationship with the kinetics of testosterone. Eur Urol. 2005;48:40–45. doi: 10.1016/j.eururo.2005.04.007. - DOI - PubMed
    1. Roy S, Loblaw A, Cheung P, et al. Prostate-specific antigen bounce after stereotactic body radiotherapy for prostate cancer: a pooled analysis of four prospective trials. Clin Oncol (R Coll Radiol) 2019;31(9):621–629. doi: 10.1016/j.clon.2019.05.001. - DOI - PubMed
    1. Horwitz EM, Levy LB, Thames HD, et al. Biochemical and clinical significance of the posttreatment prostate-specific antigen bounce for prostate cancer patients treated with external beam radiation therapy alone: a multiinstitutional pooled analysis. Cancer. 2006;107:1496–1502. doi: 10.1002/cncr.22183. - DOI - PubMed

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