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Review
. 2020 Aug 21:2020:8814531.
doi: 10.1155/2020/8814531. eCollection 2020.

Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit

Zhihui Sun  1 , Limin Yang  1 , Lihong Zhao  2 , Ranji Cui  2 , Wei Yang  2
Affiliations
Review

Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit

Zhihui Sun et al. Neural Plast. .

Abstract

Mesaconitine (MA), a diester-diterpenoid alkaloid in aconite roots, is considered to be one of the most important bioactive ingredients. In this review, we summarized its neuropharmacological effects, including analgesic effects and antiepileptiform effects. Mesaconitine can act on the central noradrenergic system and the serotonin system; behaving like the norepinephrine reuptake inhibitors and tricyclic antidepressants that increase norepinephrine levels in stress-induced depression. Therefore, the possible perspectives for future studies on the depression of MA were also discussed as well. The pharmacological effect of MA on depression is worthy of further study.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Absolute stereochemistry of mesaconitine and catabolite.
Figure 2
Figure 2
Schematic drawing of the nociceptive system with ascending and descending fibers. RF: reticular formation; PAG: periaqueductal gray; NRM: nucleus raphe magnus; NRGC: nucleus reticularis gigantocellularis; NRPG: nucleus reticularis paragigantocellularis; NRL: nucleus reticularis lateralis; 5-HT: 5-hydroxytryptamine; ENK: enkephalin; NA: noradrenaline.
Figure 3
Figure 3
Schematic drawing of the antiepileptiform mechanism of mesaconitine on a noradrenergic neuron in the pyramidal stratum of the hippocampus.
Figure 4
Figure 4
Role of β-adrenoceptors on antidepressant effect. All arrows indicate activation arrows. Gs: stimulating adenylate cyclase g protein; ATP: adenosine triphosphate; AC: adenylate cyclase; cAMP: cyclic adenosine monophosphate; PKA: protein kinase A; CREB: cAMP-response element-binding protein; BDNF: brain-derived neurotrophic factor; LTP: long-term potentiation; AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor.
See this image and copyright information in PMC

References

    1. Wang J., Jing L., Toledo-Salas J. C., Xu L. Rapid-onset antidepressant efficacy of glutamatergic system modulators: the neural plasticity hypothesis of depression. Neuroscience Bulletin. 2015;31(1):75–86. doi: 10.1007/s12264-014-1484-6. - DOI - PMC - PubMed
    1. Li N., Lee B., Liu R. J., et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010;329(5994):959–964. doi: 10.1126/science.1190287. - DOI - PMC - PubMed
    1. Farber G. A., Goldberg J. F. Regarding “combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: A double-blind randomized study”: Optimizing initial interventions. Biological Psychiatry. 2004;56(7):535–535; author reply 536. doi: 10.1016/j.biopsych.2004.07.013. - DOI - PubMed
    1. Aleksandrova L. R., Wang Y. T., Phillips A. G. Evaluation of the Wistar-Kyoto rat model of depression and the role of synaptic plasticity in depression and antidepressant response. Neuroscience and Biobehavioral Reviews. 2019;105:1–23. doi: 10.1016/j.neubiorev.2019.07.007. - DOI - PubMed
    1. Haenisch B., Bonisch H. Depression and antidepressants: insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters. Pharmacology & Therapeutics. 2011;129(3):352–368. doi: 10.1016/j.pharmthera.2010.12.002. - DOI - PubMed

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