Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan 29:1:100002.
doi: 10.1016/j.vpoa.2019.100002. eCollection 2019 May.

Efficacy of an injectable toltrazuril - gleptoferron (Forceris®) to control coccidiosis (Cystoisospora suis) in comparison with iron supplemented piglets without anticoccidial treatment

Lysanne Hiob  1   2 , Ivette Holzhausen  1   2 , Daniel Sperling  3 , Gaëlle Pagny  3 , Laurianne Meppiel  3 , Naomi Isaka  3 , Arwid Daugschies  1   2
Affiliations

Efficacy of an injectable toltrazuril - gleptoferron (Forceris®) to control coccidiosis (Cystoisospora suis) in comparison with iron supplemented piglets without anticoccidial treatment

Lysanne Hiob et al. Vet Parasitol X. .

Abstract

The efficacy and safety of an injectable combination product containing toltrazuril and gleptoferron (Forceris® - CEVA) for the control of coccidiosis due to Cystoisospora suis was investigated in neonatal piglets. The study was carried out on five European commercial pig farms in France, Germany and Spain and 122 litters consisting of 1508 piglets were selected and randomly allocated to one of two treatment groups. The first group received a single intramuscular injection per piglet of the test product, containing 45 mg toltrazuril and 200 mg iron and this was compared with a control group, which was administered a single intramuscular treatment of iron at 200 mg per piglet only. Body weights, faecal scores and oocysts counts, recorded as oocysts per gram of faeces, (OPG) were observed for 21 days. Only 1138 piglets were actually exposed to coccidiosis and data sets of these animals were selected for statistical analysis. The efficacy of the test product in the control of coccidiosis was shown in higher body weight gains, a lower percentage of animals with diarrhoea, fewer samples with positive oocysts counts as well as a lower excretion peak and a reduced area under the curve of OPG from study day (SD) 4 - SD 21. The combination product of toltrazuril and gleptoferron provided an effective alternative approach to current conventional separate treatment for the prevention of iron deficiency anaemia and coccidiosis in neonatal piglets. It reduced the numbers of potentially stressful interventions and work time.

Keywords: AUC, area under the curve; BW, body weight; CP, control group; Coccidiosis; Cystoisospora suis; Diarrhoea; FS, faecal score; Forceris®; MDBWG, mean daily body weight gain; Natural infection; OPG, oocysts per gram of faeces; Piglet; SD, study day; Toltrazuril.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Study timeline and time points (ticked boxes) of study procedures during the period Study day (SD) 0 to SD 28.
Fig. 2
Fig. 2
Mean oocyst excretion in OPG (oocysts per gram of faeces) on Study day (SD) 7, SD 9, SD 11, SD 13, SD 17 and SD 21 for piglets treated by a combination of toltrazuril and iron (IVP) and piglets treated by iron (Control).
Fig. 3
Fig. 3
Number of faecal samples with positive oocyst count by treatment group.
Fig. 4
Fig. 4
Percentage of piglets presenting diarrhoea at least once in individual farms by treatment group.
See this image and copyright information in PMC

References

    1. Aliaga-Leyton A., Webster E., Friendship R., Dewey C., Vilaça K., Peregrine A.S. An observational study on the prevalence and impact of Isospora suis in suckling piglets in southwestern Ontario, and risk factors for shedding oocysts. Can. Vet. J. 2011;52:184–188. - PMC - PubMed
    1. Driesen S.J., Fahy V.A., Carland P.G. The use of toltrazuril for the prevention of coccidiosis in piglets before weaning. Aust. Vet. J. 1995;72:139–141. - PubMed
    1. Eurostat 2007: https://ec.europa.eu/eurostat/web/products-eurostat-news/-/DDN-20170919-1.
    1. Joachim A., Mundt H.-C. Efficacy of sulfonamides and Baycox(®) against Isospora suis in experimental infections of suckling piglets. Parasitol. Res. 2011;109:1653–1659. - PubMed
    1. Joachim A., Altreuther G., Bangoura B., Charles S., Daugschies A., Hinney B., Lindsay D.S., Mundt H.-C., Ocak M., Sotiraki S. WAAVP guideline for evaluating the efficacy of anticoccidials in mammals (pigs, dogs, cattle, sheep) Vet. Parasitol. 2018;253:102–119. - PubMed

LinkOut - more resources