The Role of Lower Extremity Amputation in Chronic Limb-Threatening Ischemia
- PMID: 32904807
- PMCID: PMC7458760
- DOI: 10.1055/s-0040-1710075
The Role of Lower Extremity Amputation in Chronic Limb-Threatening Ischemia
Abstract
Chronic limb-threatening ischemia (CLTI) is a severe form of peripheral artery disease associated with high rates of limb loss. The primary goal of treatment in CLTI is limb salvage via revascularization. Multidisciplinary teams provide improved care for those with CLTI and lead to improved limb salvage rates. Not all patients are candidates for revascularization, and a subset will require major amputation. This article highlights the role of amputations in the management of CLTI, and describes the patients who should be offered primary amputation.
Keywords: amputation; artery; chronic limb-threatening ischemia; end-stage renal disease; peripheral artery disease; risk factors.
© Thieme Medical Publishers.
Conflict of interest statement
Conflict of Interest C.M. is a consultant for Bard, Cook, Cardinal Health, Boston Scientific, and Medtronic. B.E.S. is a consultant for Hypermed.
Similar articles
-
A systematic review and meta-analysis of revascularization outcomes of infrainguinal chronic limb-threatening ischemia.Eur J Vasc Endovasc Surg. 2019 Jul;58(1S):S110-S119. doi: 10.1016/j.ejvs.2019.04.013. Epub 2019 Jun 17. Eur J Vasc Endovasc Surg. 2019. PMID: 31221539
-
A systematic review and meta-analysis of revascularization outcomes of infrainguinal chronic limb-threatening ischemia.J Vasc Surg. 2019 Jun;69(6S):126S-136S. doi: 10.1016/j.jvs.2018.01.071. Epub 2019 May 28. J Vasc Surg. 2019. PMID: 31159976
-
Risk Factors for Unplanned Higher-Level Re-Amputation and Mortality after Lower Extremity Amputation in Chronic Limb-Threatening Ischemia.J Clin Med. 2024 Jul 10;13(14):4020. doi: 10.3390/jcm13144020. J Clin Med. 2024. PMID: 39064060 Free PMC article.
-
Short and long-term outcome after common femoral artery hybrid procedure in patients with intermittent claudication and chronic limb threatening ischemia.Vasa. 2021 Sep;50(5):363-371. doi: 10.1024/0301-1526/a000954. Epub 2021 May 11. Vasa. 2021. PMID: 33973817
-
Comparative 12-Month Outcomes of Drug-Coated Balloon Versus Non-Drug-Coated Balloon Revascularization Strategy in Chronic Limb-Threatening Ischemia: Results From the XLPAD Registry.Cardiovasc Revasc Med. 2020 Oct;21(10):1276-1284. doi: 10.1016/j.carrev.2020.03.030. Epub 2020 Mar 27. Cardiovasc Revasc Med. 2020. PMID: 32249170
Cited by
-
Comparative analysis of surgical and non-surgical wound approaches in diabetic foot ulcer treatment: Meta-analysis and systematic review.Int Wound J. 2024 Apr;21(4):e14601. doi: 10.1111/iwj.14601. Epub 2023 Dec 29. Int Wound J. 2024. Retraction in: Int Wound J. 2025 Apr;22(4):e70434. doi: 10.1111/iwj.70434. PMID: 38158715 Free PMC article. Retracted.
-
Intralesional Infiltrations of Arteriosclerotic Tissue Cells-Free Filtrate Reproduce Vascular Pathology in Healthy Recipient Rats.Int J Mol Sci. 2022 Jan 28;23(3):1511. doi: 10.3390/ijms23031511. Int J Mol Sci. 2022. PMID: 35163435 Free PMC article.
-
Validation of the global limb anatomical staging system in Vietnamese patients treated for chronic limb-threatening ischemia.CVIR Endovasc. 2024 Mar 5;7(1):25. doi: 10.1186/s42155-024-00433-x. CVIR Endovasc. 2024. PMID: 38441744 Free PMC article.
-
Effects of L-Ornithine-L-Aspartate on Angiogenesis and Perfusion in Subacute Hind Limb Ischemia: Preliminary Study.Biomedicines. 2024 Aug 6;12(8):1787. doi: 10.3390/biomedicines12081787. Biomedicines. 2024. PMID: 39200251 Free PMC article.
-
Retrograde endovascular intervention treating chronic limb threatening ischemia: A case report.Radiol Case Rep. 2024 Nov 27;20(2):1047-1052. doi: 10.1016/j.radcr.2024.10.141. eCollection 2025 Feb. Radiol Case Rep. 2024. PMID: 39659695 Free PMC article.
References
-
- Almasri J, Adusumalli J, Asi N.A systematic review and meta-analysis of revascularization outcomes of infrainguinal chronic limb-threatening ischemia Eur J Vasc Endovasc Surg 201958(1S):S110–S119. - PubMed
-
- Sumpio B E, Armstrong D G, Lavery L A, Andros G. The role of interdisciplinary team approach in the management of the diabetic foot: a joint statement from the Society for Vascular Surgery and the American Podiatric Medical Association. J Vasc Surg. 2010;51(06):1504–1506. - PubMed
-
- Mills J L, Sr, Conte M S, Armstrong D G. The Society for Vascular Surgery Lower Extremity Threatened Limb Classification System: risk stratification based on wound, ischemia, and foot infection (WIfI) J Vasc Surg. 2014;59(01):220–234.e1–2. - PubMed