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Review
. 2020 Sep;29(3):149-155.
doi: 10.1055/s-0040-1710075. Epub 2020 May 14.

The Role of Lower Extremity Amputation in Chronic Limb-Threatening Ischemia

Tanner I Kim  1 , Carlos Mena  2 , Bauer E Sumpio  1   2
Affiliations
Review

The Role of Lower Extremity Amputation in Chronic Limb-Threatening Ischemia

Tanner I Kim et al. Int J Angiol. 2020 Sep.

Abstract

Chronic limb-threatening ischemia (CLTI) is a severe form of peripheral artery disease associated with high rates of limb loss. The primary goal of treatment in CLTI is limb salvage via revascularization. Multidisciplinary teams provide improved care for those with CLTI and lead to improved limb salvage rates. Not all patients are candidates for revascularization, and a subset will require major amputation. This article highlights the role of amputations in the management of CLTI, and describes the patients who should be offered primary amputation.

Keywords: amputation; artery; chronic limb-threatening ischemia; end-stage renal disease; peripheral artery disease; risk factors.

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Conflict of interest statement

Conflict of Interest C.M. is a consultant for Bard, Cook, Cardinal Health, Boston Scientific, and Medtronic. B.E.S. is a consultant for Hypermed.

References

    1. Conte M S, Bradbury A W, Kolh P.Global vascular guidelines on the management of chronic limb-threatening ischemia J Vasc Surg 201969(6S):3S–125S, e40. - PMC - PubMed
    1. Almasri J, Adusumalli J, Asi N.A systematic review and meta-analysis of revascularization outcomes of infrainguinal chronic limb-threatening ischemia Eur J Vasc Endovasc Surg 201958(1S):S110–S119. - PubMed
    1. Sumpio B E, Armstrong D G, Lavery L A, Andros G. The role of interdisciplinary team approach in the management of the diabetic foot: a joint statement from the Society for Vascular Surgery and the American Podiatric Medical Association. J Vasc Surg. 2010;51(06):1504–1506. - PubMed
    1. Mills J L, Sr, Conte M S, Armstrong D G. The Society for Vascular Surgery Lower Extremity Threatened Limb Classification System: risk stratification based on wound, ischemia, and foot infection (WIfI) J Vasc Surg. 2014;59(01):220–234.e1–2. - PubMed
    1. Harris C M, Albaeni A, Thorpe R J, Norris K C, Abougergi M S. Racial factors and inpatient outcomes among patients with diabetes hospitalized with foot ulcers and foot infections, 2003-2014. PLoS One. 2019;14(05):e0216832. - PMC - PubMed