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Comparative Study
. 1988 May;8(5):2233-6.
doi: 10.1128/mcb.8.5.2233-2236.1988.

Concomitant K- and N-ras gene point mutations in clonal murine lymphoma

L E Diamond  1 , I Guerrero, A Pellicer
Affiliations
Comparative Study

Concomitant K- and N-ras gene point mutations in clonal murine lymphoma

L E Diamond et al. Mol Cell Biol. 1988 May.

Abstract

We have surveyed a panel of induced murine lymphomas for c-ras gene mutations. The K-ras gene seems to be preferentially activated in our system, and there are at least two examples of concomitant K- and N-ras gene mutations in the same tumor. This indicates that in some cases additional ras mutations may contribute to tumorigenesis and is evidence for a role of ras activation in tumor progression.

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References

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