Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun;41(6):1-11.
doi: 10.1038/s41372-020-00808-7. Epub 2020 Sep 9.

Association between maternal cervicovaginal swab positivity for Ureaplasma spp. or other microorganisms and neonatal respiratory outcome and mortality

Karen Van Mechelen  1   2 , Marisse Meeus  3 , Veerle Matheeussen  4   5 , Gilbert Donders  6   7 , Yves Jacquemyn  6 , Ludo Mahieu  3
Affiliations

Association between maternal cervicovaginal swab positivity for Ureaplasma spp. or other microorganisms and neonatal respiratory outcome and mortality

Karen Van Mechelen et al. J Perinatol. 2021 Jun.

Abstract

Objective: We investigated the association between maternal cervicovaginal cultures, its antibiotic treatment, and neonatal outcome.

Study design: This retrospective cohort study enrolled 480 neonates born prior to 32 weeks' gestation. They were divided into groups according to maternal cervicovaginal culture results. Multivariate logistic regression analysis was used to predict neonatal outcome based on maternal culture results, adjusted for perinatal risk factors and neonatal morbidities.

Result: Maternal cervicovaginal Ureaplasma colonization was independently associated with bronchopulmonary dysplasia at 36 weeks (BPD) (OR 8.34; 95% CI 1.21-57.45). In neonates with and without maternal cervicovaginal Ureaplasma colonization BPD occurred in 12.3% and 3.8%, respectively. Maternal colonization with other microorganisms was associated with a higher neonatal mortality (p = 0.002), lower gestational age (p = 0.026), and birth weight (p = 0.036).

Conclusions: This study underscores the role of the maternal cervicovaginal microbiome as a predictor of neonatal outcome. Cervicovaginal Ureaplasma colonization seems not to be an innocent bystander in the multifactorial etiology of BPD.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Agbakoba NR, Adetosoye AI, Adewole IF. Presence of mycoplasma and ureaplasma species in the vagina of women of reproductive age. West Afr J Med. 2007;26:28–31. - PubMed
    1. Donders GG, Ruban K, Bellen G, Petricevic L. Mycoplasma/Ureaplasma infection in pregnancy: to screen or not to screen. J Perinat Med. 2017;45:505–15. - PubMed
    1. Velemínský M, Tosner J. Relationship of vaginal microflora to PROM, pPROM and the risk of early-onset neonatal sepsis. Neuro Endocrinol Lett. 2008;29:205–21. - PubMed
    1. Kirchner L, Helmer H, Heinze G, Wald M, Brunbauer M, Weninger M, et al. Amnionitis with Ureaplasma urealyticum or other microbes leads to increased morbidity and prolonged hospitalization in very low birth weight infants. Eur J Obstet Gynecol Reprod Biol. 2007;134:44–50. - PubMed
    1. Mikołajczyk M, Wirstlein PK, Wróbel M, Mazela J, Chojnacka K, Skrzypezak J. Prediction of short-term newborn infectious morbidity based on maternal characteristics in patients with PPROM and Ureaplasma species infection. Ginekol Pol. 2015;86:685–8. - PubMed

LinkOut - more resources