Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Spring;14(2):83-91.
doi: 10.34172/joddd.2020.020. Epub 2020 Jun 17.

Evaluation of titanium-prepared platelet-rich fibrin and leucocyte platelet-rich fibrin in the treatment of intra-bony defects: A randomized clinical trial

Shiva Shankar Gummaluri  1 , Hirak S Bhattacharya  2 , Madhusudan Astekar  2 , Shivani Cheruvu  3
Affiliations

Evaluation of titanium-prepared platelet-rich fibrin and leucocyte platelet-rich fibrin in the treatment of intra-bony defects: A randomized clinical trial

Shiva Shankar Gummaluri et al. J Dent Res Dent Clin Dent Prospects. 2020 Spring.

Abstract

Background. Various treatment modalities, such as leucocyte platelet-rich fibrin (L-PRF), bone grafts, and membranes, have been used for the restoration of lost periodontal tissues. Titanium-prepared platelet-rich fibrin (T-PRF) has attracted attention for its proper haemocompatibility, thick fibrin meshwork, and long resorption time. The present study aimed to evaluate the effectiveness of T-PRF and L-PRF in the management of intra-bony defects based on clinical and radiographic criteria. Methods. Twenty-six subjects with 34 intra-bony 3- walled defects were divided into two groups (n=17) and treated with T-PRF or L-PRF. Clinical and radiographic measurements were recorded at baseline and 6- , 3- and 9- month intervals and tabulated on Microsoft Excel spreadsheets. For intra- and intergroup comparisons, paired and unpaired t-tests were performed. P<0.05 was set as statistically significant Results. Intra-group comparisons revealed statistically significant differences (P<0.05) from baseline in both groups regarding clinical measurements. On intergroup comparison, the T-PRF group exhibited a significantly higher defect fill compared to the L-PRF group (P<0.05). Conclusion. Within the limits of the present study, T-PRF seems to be a better alternative to L-PRF in the treatment of intra-bony defects.

Keywords: Bone regeneration; Chronic periodontitis; Debridement; Periodontal pocket; Platelet-rich fibrin.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Figure 2
Figure 2
Figure 3
Figure 3
Figure 4
Figure 4
Figure 5
Figure 5
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Chen F-M, Jin Y. Periodontal tissue engineering and regeneration: current approaches and expanding opportunities. Tissue Eng Part B Rev. 2010;16(2):219–55. doi: 10.1089/ten.TEB.2009.0562. - DOI - PubMed
    1. Panda S, Karanxha L, Goker F, Satpathy A, Taschieri S, Francetti L. et al. Autologous Platelet Concentrates in Treatment of Furcation Defects—A Systematic Review and Meta-Analysis. Int J Mol Sci. 2019;20(6):1347–63. doi: 10.3390/ijms20061347. - DOI - PMC - PubMed
    1. Trombelli L, Heitz-Mayfield LJ, Needleman I, Moles D, Scabbia A. A systematic review of graft materials and biological agents for periodontal intraosseous defects. J Clin Periodontol. 2002;29(s3):117–35. doi: 10.1034/j.1600-051x.29.s3.7.x. - DOI - PubMed
    1. Mathur A, Bains VK, Gupta V, Jhingran R, Singh G. Evaluation of intrabony defects treated with platelet-rich fibrin or autogenous bone graft: A comparative analysis. Eur J Dent. 2015;9(01):100–8. doi: 10.4103/1305-7456.149653. - DOI - PMC - PubMed
    1. Chatterjee A, Debnath K. Comparative evaluation of growth factors from platelet concentrates: An in vitro study. J Indian Soc Periodontol. 2019;23(4):322–8. doi: 10.4103/jisp.jisp_678_18. - DOI - PMC - PubMed

LinkOut - more resources