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Case Reports
. 2020 Aug 22:2020:8818905.
doi: 10.1155/2020/8818905. eCollection 2020.

Diffuse Spontaneous Laryngeal Hemorrhage with Trastuzumab

Lauren Klute  1 , Matthew Solverson  1 , Christopher M Bingcang  1 , Jayme R Dowdall  1
Affiliations
Case Reports

Diffuse Spontaneous Laryngeal Hemorrhage with Trastuzumab

Lauren Klute et al. Case Rep Otolaryngol. .

Abstract

Drug-induced epithelial hemorrhage of the endolarynx is an unusual etiology of hemoptysis. We present a case of hemoptysis in a young female patient undergoing treatment for metastatic breast cancer with trastuzumab emtansine. Though previously associated with diffuse spontaneous hemorrhage of the gingiva, there have not been reports of laryngeal hemorrhage with trastuzumab emtansine treatment. In this case report, we suggest that trastuzumab emtansine played a contributory role in the development of diffuse epithelial laryngeal hemorrhage and describe the pathophysiology, history, laryngoscopic findings, and management of this condition.

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Conflict of interest statement

The authors declare that they have no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
Bilateral vocal fold edema with ulceration of vocal folds; supraglottic and glottic epithelial bleeding.
Figure 2
Figure 2
Petechiae of the supraglottis and false vocal folds; scabbing of the interarytenoid region, glottis, and supraglottis.
See this image and copyright information in PMC

References

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