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Review
. 2020 Apr 23;6(3):147-157.
doi: 10.1016/j.cdtm.2020.03.004. eCollection 2020 Sep.

Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges

Zhi Zhu  1 , Ying-Bo Gong  1 , Hui-Mian Xu  1
Affiliations
Review

Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges

Zhi Zhu et al. Chronic Dis Transl Med. .

Abstract

Gastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival rate after resection in most patients with advanced stage. Clinical trials show that neoadjuvant approaches confer a significant survival advantage for resectable locally advanced gastric cancer. The specific advantages of chemoradiotherapy compared with chemotherapy have not been clarified; optimal regimens and cycles, particularly in the preoperative setting, should be studied further; and trials aimed at determining the role of targeted and immunological therapies should be conducted.

Keywords: Chemotherapy; Gastric cancer; Neoadjuvant therapy; Radiotherapy.

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Conflict of interest statement

None.

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References

    1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. D'Ugo D., Rausei S., Biondi A., Persiani R. Preoperative treatment and surgery in gastric cancer: friends or foes. Lancet Oncol. 2009;10:191–195. doi: 10.1016/S1470-2045(09)70021-X. - DOI - PubMed
    1. Wilke H., Preusser P., Fink U. Preoperative chemotherapy in locally advanced and nonresectable gastric cancer: a phase II study with etoposide, doxorubicin, and cisplatin. J Clin Oncol. 1989;7:1318–1326. doi: 10.1200/JCO.1989.7.9.1318. - DOI - PubMed
    1. Cunningham D., Allum W.H., Stenning S.P. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006;355:11–20. doi: 10.1056/NEJMoa055531. - DOI - PubMed
    1. Ychou M., Boige V., Pignon J.P. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. J Clin Oncol. 2011;29:1715–1721. doi: 10.1200/JCO.2010.33.0597. - DOI - PubMed