Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul;199(7):2612-2620.
doi: 10.1007/s12011-020-02360-z. Epub 2020 Sep 9.

Protective Effect of Boric Acid and Omega-3 on Myocardial Infarction in an Experimental Rat Model

Hadi Karimkhani  1 , Mete Özkoç  2 , Paria Shojaolsadati  3 , Kubilay Uzuner  4 , Dilek Burukoglu Donmez  5 , Güngör Kanbak  2
Affiliations

Protective Effect of Boric Acid and Omega-3 on Myocardial Infarction in an Experimental Rat Model

Hadi Karimkhani et al. Biol Trace Elem Res. 2021 Jul.

Abstract

Boric acid and omega-3 are used as essential elements for both animal and human health. Many researchers have shown these beneficial effects on cardiac and inflammatory markers. This study aims to evaluate cardiac protective effect of boric acid and omega-3 against MI (myocardial infarction), probably due to the suppression of pro-inflammatory cytokines of natriuretic peptides in rats. Fifty male Sprague-Dawley rats were randomly divided into five groups: control, MI, MI+boric acid, MI+omega-3, and MI+boric acid+omega-3. Saline solution (2 ml/day), omega-3 (800 mg/kg/day), and boric acid (100 mg/kg/day)+omega-3 (800 mg/kg/day) were orally administered to the relevant groups throughout the 28 days. To constitute the MI model, the rats were exposed to isoproterenol-HCl (ISO) (200 mg/kg, S.C.) on the 27th and 28th. In the MI group, serum levels of CK-MB, BNP, and TNF-α are increased significantly. Also, ST waves and heart rates were higher in the MI than the control. These results demonstrate that biochemical results healed in MI+boric acid, MI+omega-3, and MI+boric acid+omega-3 groups compared MI group. ECG and light microscope results supported the findings as well. The statistical analysis showed that boric acid and/or omega-3 has protective effects on cellular damage in MI.

Keywords: Boric acid; Electrocardiography (ECG); Myocardial infarction; Omega-3; Rat model.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Vutharadhi S, Jolapuram U, Kodidhela LD (2017) Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation. Biomed Pharmacother 85:239–247. https://doi.org/10.1016/j.biopha.2016.10.103
    1. Kumar S, Jahangir Alam M, Prabhakar P, Ahmad S, Maulik SK, Sharma M, Goswami SK (2017) Proteomic analysis of the protective effects of aqueous bark extract of Terminalia arjuna (Roxb.) on isoproterenol-induced cardiac hypertrophy in rats. J Ethnopharmacol 198:98–108. https://doi.org/10.1016/j.jep.2016.12.050 - DOI - PubMed
    1. Zhou P, Cheng CP, Li T, Ferrario CM, Cheng HJ (2015) Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure. Ther Adv Cardiovasc Dis 9(6):342–353. https://doi.org/10.1177/1753944715587424 - DOI - PubMed
    1. Watanabe Y, Tatsuno I (2020) Prevention of cardiovascular events with omega-3 polyunsaturated fatty acids and the mechanism involved. J Atheroscler Thromb 27(3):183–198. https://doi.org/10.5551/jat.50658 - DOI - PubMed - PMC
    1. Mozaffarian D, Wu JH (2011) Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 58(20):2047–2067. https://doi.org/10.1016/j.jacc.2011.06.063 - DOI - PubMed

Grants and funding

LinkOut - more resources