Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar;156(6):753-776.
doi: 10.1111/jnc.15166. Epub 2020 Oct 7.

Alzheimer's disease and type 2 diabetes mellitus: A systematic review of proteomic studies

Jessica Diniz Pereira  1 , Vanessa Gomes Fraga  1 , Anna Luiza Morais Santos  1 , Maria das Graças Carvalho  1 , Paulo Caramelli  2 , Karina Braga Gomes  1
Affiliations

Alzheimer's disease and type 2 diabetes mellitus: A systematic review of proteomic studies

Jessica Diniz Pereira et al. J Neurochem. 2021 Mar.

Abstract

Similar to dementia, the risk for developing type 2 diabetes mellitus (T2DM) increases with age, and T2DM also increases the risk for dementia, particularly Alzheimer's disease (AD). Although T2DM is primarily a peripheral disorder and AD is a central nervous system disease, both share some common features as they are chronic and complex diseases, and both show involvement of oxidative stress and inflammation in their progression. These characteristics suggest that T2DM may be associated with AD, which gave rise to a new term, type 3 diabetes (T3DM). In this study, we searched for matching peripheral proteomic biomarkers of AD and T2DM based in a systematic review of the available literature. We identified 17 common biomarkers that were differentially expressed in both patients with AD or T2DM when compared with healthy controls. These biomarkers could provide a useful workflow for screening T2DM patients at risk to develop AD.

Keywords: Alzheimer's disease; Proteomics; peripheral biomarkers; type 2 diabetes mellitus.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

REFERENCES

    1. Abdulwahab, R. A., Alaiya, A., Shinwari, Z., Allaith, A. A., & Giha, H. A. (2019). LC MS/MS proteomic analysis revealed novel associations of 37 proteins with T2DM and notable upregulation of immunoglobulins. International Journal of Molecular Medicine, 43, 2118-2132. https://doi.org/10.3892/ijmm.2019.4127
    1. Adams, J. N., Cox, A. J., Freedman, B. I., Langefeld, C. D., Carr, J. J., & Bowden, D. W. (2013). Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study. Cardiovascular Diabetology, 12, 31.
    1. Aguilar Salinas, C. A., Cruz-Bautista, I., Mehta, R., Villarreal-Molina, M. T., Perez, F. J., Tusie-Luna, M. T., & Canizales-Quinteros, S. (2007). The ATP-binding cassette transporter subfamily A member 1 (ABC-A1) and type 2 diabetes: An association beyond HDL cholesterol. Current. Diabetes. Reviews., 3, 264-267.
    1. Aslam, B., Basit, M., Nisar, M. A., Khurshid, M., & Rasool, M. H. (2017). Proteomics: Technologies and their applications. Journal of Chromatographic Science, 55, 182-196. https://doi.org/10.1093/chromsci/bmw167
    1. Beeri, M. S., Lin, H. M., Sano, M., Ravona-Springer, R., Liu, X., Bendlin, B. B., … Ehrenberg, S. (2018). Association of the haptoglobin gene polymorphism with cognitive function and decline in elderly African American adults with type 2 diabetes: Findings from the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) study. JAMA Network Open, 1, e184458-e184458.

Publication types

LinkOut - more resources