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Review
. 2020 Dec;63(14):576-581.
doi: 10.1002/jlcr.3881. Epub 2020 Oct 8.

Radiolabeled hormones in insulin research, a minireview

Jiří Jiráček  1 , Lenka Žáková  1 , Aleš Marek  1
Affiliations
Review

Radiolabeled hormones in insulin research, a minireview

Jiří Jiráček et al. J Labelled Comp Radiopharm. 2020 Dec.

Abstract

Preparation of both 125 I-labeled insulin and insulin-like growth factor 1 (IGF-1) was critical because it enabled a detailed characterization of binding properties of these important hormones towards their cognate transmembrane receptors. Binding modes of hundreds of hormone derivatives were analyzed using competition radioligand binding assays. This effort has resulted in development of six insulin analogs that are today clinically used for the treatment of diabetes. Here, we will briefly summarize a history of insulin research employing iodinated hormones.

Keywords: IGF; assay; binding; hormone; insulin.

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References

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