Extensive Tumor Thrombosis of Portal Venous System Demonstrated on 68Ga-DOTATATE and 68Ga-NODAGA-LM3 PET/CT in a Patient With Well-Differentiated Neuroendocrine Tumor
- PMID: 32910048
- DOI: 10.1097/RLU.0000000000003262
Extensive Tumor Thrombosis of Portal Venous System Demonstrated on 68Ga-DOTATATE and 68Ga-NODAGA-LM3 PET/CT in a Patient With Well-Differentiated Neuroendocrine Tumor
Abstract
We present a case with a pancreatic neuroendocrine tumor and extensive tumor thrombosis in portal venous system. The tumor was first identified on contrast-enhanced CT and later confirmed using Ga-DOTATATE and Ga-NODAGA-LM3 PET/CT. Both tracers demonstrated similar pattern with higher tumor affinity and tumor-to-background ratio using Ga-NODAGA-LM3.
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References
-
- De Robertis R, Paiella S, Cardobi N, et al. Tumor thrombosis: a peculiar finding associated with pancreatic neuroendocrine neoplasms. A pictorial essay. Abdom Radiol (NY). 2018;43:613–619.
-
- Balachandran A, Tamm EP, Bhosale PR, et al. Venous tumor thrombus in nonfunctional pancreatic neuroendocrine tumors. AJR Am J Roentgenol. 2012;199:602–608.
-
- Bok EJ, Cho KJ, Williams DM, et al. Venous involvement in islet cell tumors of the pancreas. AJR Am J Roentgenol. 1984;142:319–322.
-
- Prakash L, Lee JE, Yao J, et al. Role and operative technique of portal venous tumor thrombectomy in patients with pancreatic neuroendocrine tumors. J Gastrointest Surg. 2015;19:2011–2018.
-
- Rodriguez RA, Overton H, Morris KT. Pancreatic neuroendocrine tumor with splenic vein tumor thrombus: a case report. Int J Surg Case Rep. 2014;5:1271–1274.
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