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. 2021 Mar;259(3):643-652.
doi: 10.1007/s00417-020-04913-3. Epub 2020 Sep 10.

The impact of macular edema on microvascular and metabolic alterations in retinitis pigmentosa

Margarita G Todorova  1   2 , Hendrik P N Scholl  3   4 , Maria Della Volpe Waizel  3
Affiliations

The impact of macular edema on microvascular and metabolic alterations in retinitis pigmentosa

Margarita G Todorova et al. Graefes Arch Clin Exp Ophthalmol. 2021 Mar.

Erratum in

Abstract

Purpose: The primary aim of our study was to evaluate retinal microvascular anomalies recorded with optical coherence tomography angiography (OCTA) and the retinal metabolic function measured with retinal oximetry (RO) in patients with retinitis pigmentosa (RP). The secondary aim of the study was to link the presence of macular edema to microvascular and metabolic parameters in RP.

Methods: OCTA and RO were performed on 94 eyes: 64 eyes diagnosed with RP with (ME-RP) and without (no-ME-RP) macular edema were compared with 30 control eyes. Study end points were as follows: mean superficial (FAZ-S) and deep foveal avascular zone (FAZ-D) determined by OCTA. In addition, we evaluated the mean arterial (A-SO2; %), venular (V-SO2; %) oxygen saturation, their difference (A-V SO2; %), as well as the corresponding mean diameter of the retinal arterioles (D-A; μm) and venules (D-V; μm).

Results: RP patients differed from controls by enlarged FAZ-S and FAZ-D (p ≤ 0.001), attenuated retinal vessels (p ≤ 0.001), and increased retinal vessel oxygen saturation (p ≤ 0.010). Subgroup analyses within RP patients revealed more pronounced alterations of microvascular parameters and metabolic function in the presence of macular edema. In the no-ME-RP subgroup, significant interactions were present between FAZ-S, A-SO2, and V-SO2, whereas in the ME-RP subgroup, we found significant correlations between FAZ-D and D-A.

Conclusion: A combined microvascular structure-metabolic function approach enhances our understanding of inherited retinal diseases. The presence of macular edema in RP seems to be a result of more altered microvascular-metabolic function. Macular edema should thus be taken into consideration when evaluating microvascular and/or metabolic changes in RP.

Keywords: Foveal avascular zone; Inherited retinal diseases; Macular edema; Metabolic function; Optical coherence tomography angiography; Retinal oximetry; Retinal vessel diameter; Retinitis pigmentosa.

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