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Comparative Study
. 2021 Feb;49(1):145-148.
doi: 10.1007/s15010-020-01523-3. Epub 2020 Sep 10.

Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings

Jens T Van Praet  1   2 , Ann-Sofie Coene  3 , Kris Van De Moortele  4 , Patrick Descheemaeker  5 , Marijke Reynders  5
Affiliations
Comparative Study

Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings

Jens T Van Praet et al. Infection. 2021 Feb.

Abstract

A subset of patients with Covid-19 presents with negative RT-PCR screening but suspect CT findings. Using four commercially available anti-SARS-CoV-2 IgG immuno-assays, we found this subset constituted 9.2% of all consecutively admitted outpatients with Covid-19 in our hospital. Clinical specificity for Covid-19 of some N protein-based immuno-assays was suboptimal, as positive results were observed in control patients with recent common human coronavirus, influenza B and adenovirus infections.

Keywords: Covid-19; ELISA; SARS-CoV-2; Serology.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Serological results of patients with negative RT-PCR nasopharyngeal screening suspect CT findings and positive serology testing, in function of the day of self-reported symptom onset. The second line denotes the day of sampling in function of onset of symptoms. Each line represents an individual patient. Pos denotes a positive, Neg a negative and Bor a borderline test result. A blank cell denotes no serum sample was available for testing
See this image and copyright information in PMC

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