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Review
. 2020 Sep 10;22(11):132.
doi: 10.1007/s11886-020-01385-z.

Advances in the Genetics and Genomics of Heart Failure

Nosheen Reza  1 , Anjali Tiku Owens  2
Affiliations
Review

Advances in the Genetics and Genomics of Heart Failure

Nosheen Reza et al. Curr Cardiol Rep. .

Abstract

Purpose of review: The purpose of this review is to provide an update on the recent advances in the genetics and genomics of dilated cardiomyopathy and heart failure.

Recent findings: Over the last decade, the approach to the discovery of the genetic contribution to heart failure has evolved from investigation of rare variants implicated in Mendelian cardiomyopathies through linkage studies and candidate gene studies to the exploration of the contribution of common variants through large-scale genome-wide association and genome-first studies. The combination and integration of multiple of case-control heart failure cohorts, refinement of the heart failure phenotype, and utilization of large biobanks linked to electronic health records have advanced the understanding of the heritability of heart failure.

Keywords: Dilated cardiomyopathy; Genetics; Genomics; Heart failure; Pharmacogenomics.

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Figures

Fig. 1
Fig. 1
Spectrum of approaches and study types for the investigation of the genetic contribution of rare and common variants to heart failure risk
See this image and copyright information in PMC

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