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Meta-Analysis
. 2021 Aug;44(4):2069-2077.
doi: 10.1007/s10143-020-01388-y. Epub 2020 Sep 10.

Role of prophylactic antiepileptic drugs in chronic subdural hematoma-a systematic review and meta-analysis

Deivanai Sundaram Nachiappan  1 , Kanwaljeet Garg  2
Affiliations
Meta-Analysis

Role of prophylactic antiepileptic drugs in chronic subdural hematoma-a systematic review and meta-analysis

Deivanai Sundaram Nachiappan et al. Neurosurg Rev. 2021 Aug.

Abstract

Chronic subdural hematoma is a common neurosurgical pathology, which is more commonly seen in the elderly age group. Few patients with chronic subdural hematoma (cSDH) can have seizures-either before or after surgical intervention. Reported incidence of seizures varies from 0.7-18.5% in patients with cSDH. Many factors which have been proposed to increase the risk of seizures in these patients include the presence of encapsulated membranes, occult cortical injury, mass effect, or an acute hemorrhage. The role of prophylactic antiepileptic drugs is not very clear in cSDH. We reviewed the currently available evidence for the use of prophylactic antiepileptic drugs (AEDs) in patients with cSDH. We included 13 studies in the systematic review and 6 studies compared the incidence of seizures in patients who received antiepileptic drugs with those who did not. Our review did not find any significant reduction in the incidence of seizures in patients with cSDH following administration of antiepileptic drugs.

Keywords: Anticonvulsant drugs; Antiepileptic drugs; Chronic subdural hematoma; Seizures; Subdural hematoma.

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