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. 2020 Sep 9;107(5):768-769.
doi: 10.1016/j.neuron.2020.08.007.

Single Cell Technologies Define New Therapeutic Avenues for Huntington's Disease

Tamara Maiuri  1 , Ray Truant  2
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Single Cell Technologies Define New Therapeutic Avenues for Huntington's Disease

Tamara Maiuri et al. Neuron. .
Free article

Abstract

Using two independent single-cell transcriptomics technologies, Lee et al. have cataloged transcriptional changes in the subset of striatal neurons hit hardest in Huntington's disease. One downregulated pathway, oxidative phosphorylation, may also explain their observed release of mitochondrial-encoded RNAs.

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