Phage-Bacteria Associations: Analyze. Match. Develop Therapies

Shaqed Carasso¹, Haitham Hajjo², Naama Geva-Zatorsky³

Affiliations

¹ Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Technion Integrated Cancer Center (TICC), Haifa 3525433, Israel.
² Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Technion Integrated Cancer Center (TICC), Haifa 3525433, Israel; Department of Immunology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel; Department of Neuroscience, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel.
³ Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Technion Integrated Cancer Center (TICC), Haifa 3525433, Israel; Canadian Institute for Advanced Research (CIFAR) Azrieli Global Scholar, MaRs Centre, West Tower 661 University Ave., Suite 505, Toronto, ON M5G 1m1, Canada. Electronic address: naama_gz@technion.ac.il.

PMID: 32910916
DOI: 10.1016/j.chom.2020.08.009

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Phage-Bacteria Associations: Analyze. Match. Develop Therapies

Shaqed Carasso et al. Cell Host Microbe. 2020.

Free article

. 2020 Sep 9;28(3):353-355.

doi: 10.1016/j.chom.2020.08.009.

Authors

Shaqed Carasso¹, Haitham Hajjo², Naama Geva-Zatorsky³

Affiliations

¹ Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Technion Integrated Cancer Center (TICC), Haifa 3525433, Israel.
² Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Technion Integrated Cancer Center (TICC), Haifa 3525433, Israel; Department of Immunology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel; Department of Neuroscience, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel.
³ Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Technion Integrated Cancer Center (TICC), Haifa 3525433, Israel; Canadian Institute for Advanced Research (CIFAR) Azrieli Global Scholar, MaRs Centre, West Tower 661 University Ave., Suite 505, Toronto, ON M5G 1m1, Canada. Electronic address: naama_gz@technion.ac.il.

PMID: 32910916
DOI: 10.1016/j.chom.2020.08.009

Abstract

Although bacteriophages are highly abundant in the gut microbiome, little is known about their potential effects on gut bacteria. In this issue of Cell Host & Microbe, Hryckowian et al. (2020) and Fujimoto et al. (2020) combined metagenomic analysis and experiments to study phage-bacteria associations in order to develop future research tools and therapies.

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Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy against Pathobionts.
Fujimoto K, Kimura Y, Shimohigoshi M, Satoh T, Sato S, Tremmel G, Uematsu M, Kawaguchi Y, Usui Y, Nakano Y, Hayashi T, Kashima K, Yuki Y, Yamaguchi K, Furukawa Y, Kakuta M, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S. Fujimoto K, et al. Cell Host Microbe. 2020 Sep 9;28(3):380-389.e9. doi: 10.1016/j.chom.2020.06.005. Epub 2020 Jul 10. Cell Host Microbe. 2020. PMID: 32652061
Bacteroides thetaiotaomicron-Infecting Bacteriophage Isolates Inform Sequence-Based Host Range Predictions.
Hryckowian AJ, Merrill BD, Porter NT, Van Treuren W, Nelson EJ, Garlena RA, Russell DA, Martens EC, Sonnenburg JL. Hryckowian AJ, et al. Cell Host Microbe. 2020 Sep 9;28(3):371-379.e5. doi: 10.1016/j.chom.2020.06.011. Epub 2020 Jul 10. Cell Host Microbe. 2020. PMID: 32652063 Free PMC article.

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Phage-Bacteria Associations: Analyze. Match. Develop Therapies

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Phage-Bacteria Associations: Analyze. Match. Develop Therapies

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