Clostridioides difficile: Sometimes It Pays To Be Difficult

Matthew L Jenior¹, Jason A Papin²

Affiliations

¹ Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
² Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; Department of Medicine, Division of Infectious Diseases & International Health, University of Virginia, Charlottesville, VA, USA; Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, USA. Electronic address: papin@virginia.edu.

PMID: 32910918
DOI: 10.1016/j.chom.2020.08.010

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Clostridioides difficile: Sometimes It Pays To Be Difficult

Matthew L Jenior et al. Cell Host Microbe. 2020.

Free article

. 2020 Sep 9;28(3):358-359.

doi: 10.1016/j.chom.2020.08.010.

Authors

Matthew L Jenior¹, Jason A Papin²

Affiliations

¹ Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
² Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; Department of Medicine, Division of Infectious Diseases & International Health, University of Virginia, Charlottesville, VA, USA; Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, USA. Electronic address: papin@virginia.edu.

PMID: 32910918
DOI: 10.1016/j.chom.2020.08.010

Abstract

In this issue of Cell Host & Microbe, publications from Bushman et al. (2020) and Knippel et al. (2020) outline elements of host epithelial damage or inflammation that Clostridioides difficile subverts, enabling continued growth. These mechanisms provide insight into how this important pathogen influences the gut environment to promote its metabolic strategy during infection.

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Clostridioides difficile Senses and Hijacks Host Heme for Incorporation into an Oxidative Stress Defense System.
Knippel RJ, Wexler AG, Miller JM, Beavers WN, Weiss A, de Crécy-Lagard V, Edmonds KA, Giedroc DP, Skaar EP. Knippel RJ, et al. Cell Host Microbe. 2020 Sep 9;28(3):411-421.e6. doi: 10.1016/j.chom.2020.05.015. Epub 2020 Jun 10. Cell Host Microbe. 2020. PMID: 32526159 Free PMC article.
Multi-omic Analysis of the Interaction between Clostridioides difficile Infection and Pediatric Inflammatory Bowel Disease.
Bushman FD, Conrad M, Ren Y, Zhao C, Gu C, Petucci C, Kim MS, Abbas A, Downes KJ, Devas N, Mattei LM, Breton J, Kelsen J, Marakos S, Galgano A, Kachelries K, Erlichman J, Hart JL, Moraskie M, Kim D, Zhang H, Hofstaedter CE, Wu GD, Lewis JD, Zackular JP, Li H, Bittinger K, Baldassano R. Bushman FD, et al. Cell Host Microbe. 2020 Sep 9;28(3):422-433.e7. doi: 10.1016/j.chom.2020.07.020. Epub 2020 Aug 20. Cell Host Microbe. 2020. PMID: 32822584 Free PMC article.

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Clostridioides difficile: Sometimes It Pays To Be Difficult

Affiliations

Clostridioides difficile: Sometimes It Pays To Be Difficult

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