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Review
. 2020 Nov 1:205:112667.
doi: 10.1016/j.ejmech.2020.112667. Epub 2020 Jul 29.

New drug approvals for 2019: Synthesis and clinical applications

Shuo Yuan  1 , Bin Yu  2 , Hong-Min Liu  1
Affiliations
Review

New drug approvals for 2019: Synthesis and clinical applications

Shuo Yuan et al. Eur J Med Chem. .

Abstract

48 new drugs including 38 chemical entities (33 new chemical entities, 3 new diagnostic agents, and 2 payloads of antibody drug conjugates) and 10 biologics were approved by the U.S. Food and Drug Administration (FDA) during 2019. These marketed new drugs represent privileged structures and novel action of mechanism, and thus can be served as leads to discover new drugs with the similar biological targets and improved therapeutic efficacy. This review aims to provide an overview regarding the synthetic approaches of 33 new chemical entities approved by the FDA in 2019 and their clinical applications.

Keywords: Chemical synthesis; Clinical applications; New drugs.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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