Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Oct 1;88(7):514-516.
doi: 10.1016/j.biopsych.2020.07.010.

Cumulative Stress Burden on Motivated Action Revealed

Affiliations
Comment

Cumulative Stress Burden on Motivated Action Revealed

Henry W Kietzman et al. Biol Psychiatry. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Separating seeking and taking.
Barthas and colleagues (3) develop a procedure that rapidly captures – and dissociates – the mouse’s propensity to work for palatable foods and consume those foods. The task provides a platform for quantifying stress burden on motivated behavior over time. Illustration credit: Aylet Allen.

Comment on

References

    1. Dias-Ferreira E, Sousa JC, Melo I, Morgado P, Mesquita AR, Cerqueira JJ, Costa RM, Sousa N. Chronic stress causes frontostriatal reorganization and affects decision-making. Science. 2009;325(5940):621–5. - PubMed
    1. Gourley SL, Swanson AM, Jacobs AM, Howell JL, Mo M, Dileone RJ, Koleske AJ, Taylor JR. Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding. Proc Natl Acad Sci U S A. 2012;109(50):20714–9. - PMC - PubMed
    1. Barthas F, Hu MY, Siniscalchi MJ, Ali F, Mineur YS, Picciotto MR, Kwan AC. Cumulative Effects of Social Stress on Reward-Guided Actions and Prefrontal Cortical Activity. Biol Psychiatry. 2020. - PMC - PubMed
    1. Covington HE 3rd, Newman EL, Leonard MZ, Miczek KA. Translational models of adaptive and excessive fighting: an emerging role for neural circuits in pathological aggression. F1000Res. 2019;8. - PMC - PubMed
    1. Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, Laplant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 2007;131(2):391–404. - PubMed

Publication types