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Comment
. 2020 Nov;19(11):754.
doi: 10.1038/d41573-020-00161-6.

Novel chemistry for covalent inhibitors

Megan Cully
Comment

Novel chemistry for covalent inhibitors

Megan Cully. Nat Rev Drug Discov. 2020 Nov.
No abstract available

Keywords: Cancer; Chemistry; Drug discovery.

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Comment on

  • Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery.
    Brighty GJ, Botham RC, Li S, Nelson L, Mortenson DE, Li G, Morisseau C, Wang H, Hammock BD, Sharpless KB, Kelly JW. Brighty GJ, et al. Nat Chem. 2020 Oct;12(10):906-913. doi: 10.1038/s41557-020-0530-4. Epub 2020 Aug 31. Nat Chem. 2020. PMID: 32868886 Free PMC article.
  • Covalent inhibition of NSD1 histone methyltransferase.
    Huang H, Howard CA, Zari S, Cho HJ, Shukla S, Li H, Ndoj J, González-Alonso P, Nikolaidis C, Abbott J, Rogawski DS, Potopnyk MA, Kempinska K, Miao H, Purohit T, Henderson A, Mapp A, Sulis ML, Ferrando A, Grembecka J, Cierpicki T. Huang H, et al. Nat Chem Biol. 2020 Dec;16(12):1403-1410. doi: 10.1038/s41589-020-0626-6. Epub 2020 Aug 31. Nat Chem Biol. 2020. PMID: 32868895 Free PMC article.

References

    1. Huang, H. et al. Covalent inhibition of NSD1 histone methyltransferase. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0626-6 (2020)
    1. Brighty, G.J. et al. Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery. Nat. Chem. https://doi.org/10.1038/s41557-020-0530-4 (2020)

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