Review
doi: 10.1021/acs.jcim.0c00861.
Epub 2020 Sep 11.
What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?
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- PMID: 32914973
- DOI: 10.1021/acs.jcim.0c00861
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Review
What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?
J Chem Inf Model.
.
Free article
Abstract
Massive drug repurposing (or repositioning) campaigns are trying to find potential antiviral treatments for COVID-19. Many involve experimental or virtual screening of libraries of compounds previously proven safe in humans-"old drugs". In 20 years of these efforts in many other diseases, never has a new therapeutic hypothesis derived from screening of old drugs in a lab led to the drug being approved for the new indication.
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