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Review
. 2020 Dec 28;60(12):5727-5729.
doi: 10.1021/acs.jcim.0c00861. Epub 2020 Sep 11.

What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?

Aled Edwards  1
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Free article
Review

What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?

Aled Edwards. J Chem Inf Model. .
Free article

Abstract

Massive drug repurposing (or repositioning) campaigns are trying to find potential antiviral treatments for COVID-19. Many involve experimental or virtual screening of libraries of compounds previously proven safe in humans-"old drugs". In 20 years of these efforts in many other diseases, never has a new therapeutic hypothesis derived from screening of old drugs in a lab led to the drug being approved for the new indication.

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