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. 2020 Dec;30(12):4958-4966.
doi: 10.1007/s11695-020-04956-9. Epub 2020 Sep 11.

Gut Microbiota Modifications and Weight Regain in Morbidly Obese Women After Roux-en-Y Gastric Bypass

Silvia Leite Faria #  1   2 , Andrey Santos #  3 , Daniéla Oliveira Magro  4 , Everton Cazzo  4 , Heloisa Balan Assalin  5 , Dioze Guadagnini  5 , Flavio Teixeira Vieira  1 , Eliane Said Dutra  1 , Mario José Abdalla Saad  5 , Marina K Ito  1
Affiliations

Gut Microbiota Modifications and Weight Regain in Morbidly Obese Women After Roux-en-Y Gastric Bypass

Silvia Leite Faria et al. Obes Surg. 2020 Dec.

Abstract

Introduction: The relationship between late post-bariatric surgery weight regain and gut microbiota is not completely understood.

Objective: To analyze the profile of gut microbiota among patients with and without late weight regain after post-Roux-en-Y gastric bypass (RYGB) and to compare it with a control group (CG) comprised of obese Brazilian individuals.

Methods: This is a cross-sectional study which enrolled 34 morbidly obese women divided into 3 groups: post-Roux-en-Y gastric bypass without (RYGB_non-regain), and with weight regain (RYGB_regain) at least 5 years after surgery, and a CG of preoperative individuals. Gut microbiota was determined by metagenomic analyses.

Results: The alpha diversity was higher in groups RYGB non-regain and RYGB regain when compared with CG (p < 0.05). Both RYGB non-regain and RYGB regain groups showed a lower abundance of the phylum Bacteroidetes when compared with CG (p < 0.01). The genera Bacteroides and SMB53 were increased in CG (p < 0.05). Group RYGB non-regain showed more abundance of the Akkermansia genus when compared with CG and group RYGB regain (p < 0.05). RYGB non-regain showed a greater abundance of the Phascolarctobacterium genus and lower of the SMB53 genus when compared with CG (p < 0.05). RYGB non-regain showed a greater abundance of the Phascolarctobacterium genus and a lower of the SMB53 genus when compared with CG (p < 0.05).

Conclusion: The gut microbiota of individuals which presented late weight regain after RYGB was significantly different in comparison to individuals with a successful weight loss, a finding that points towards a significant role of gut microbiota on weight loss and maintenance after surgery.

Keywords: Bariatric surgery; Gastric bypass; Microbiota; Obesity; Weight loss.

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