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Comment
. 2020 Dec:196:222-226.
doi: 10.1016/j.thromres.2020.08.027. Epub 2020 Aug 21.

Utility of D-dimers and intermediate-dose prophylaxis for venous thromboembolism in critically ill patients with COVID-19

Maxime G Zermatten  1 , Olivier Pantet  2 , Francisco Gomez  1 , Antoine Schneider  2 , Marie Méan  3 , Lucia Mazzolai  4 , Olivier Hugli  5 , Pierre-Alexandre Bart  3 , Matthaios Papadimitriou-Olivgeris  6 , Lorenzo Alberio  7 ; COVID-19 Interdisciplinary Collaboration - COVIDIC initiative
Affiliations
Comment

Utility of D-dimers and intermediate-dose prophylaxis for venous thromboembolism in critically ill patients with COVID-19

Maxime G Zermatten et al. Thromb Res. 2020 Dec.
No abstract available

Keywords: COVID-19; Coagulopathy; D-dimers; Pulmonary embolism; Thrombosis.

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Conflict of interest statement

The authors do not have competing interest to declare in relation to this manuscript.

Figures

Fig. 1
Fig. 1
Timing of V/ATE. Panel A: Number of patients in ICU and VTE diagnosed [open blue columns: VTE occurring before 2 days of hospitalisation (VTE ≤ 1 day); full red columns: VTE occurring starting at day 2 of hospitalisation (VTE > 1 day)]. Panel B: Cumulative proportion of VTE (continuous blue line) and evolution of the number of patients discharged from ICU without VTE (dotted blue line) and of patients still in the ICU (black line). Panel C: Cumulative proportion of ATE (continuous red line), evolution of the number of patients discharged from ICU without ATE (dotted red line) and of patients still in the ICU (black line). A/VTE, arterial and venous thromboembolic events; ICU, intensive care unit. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Fig. 2
Fig. 2
Diagnostic value of D-dimers in patients with VTE-imaging (n = 45). Maximal D-dimers until discharge for patients without VTE and maximal D-dimers until VTE-diagnostics were included. Panel A: Maximal D-dimers in patients with and without VTE. Comparisons between the groups were performed using Mann-Whitney test. Error bars represent median and interquartile range. Panel B represent the ROC-curve; Panel B: ROC-curve for maximal D-dimer values; Panel C: Likelihood ratios of D-dimers intervals for prediction of the VTE-occurrence based on patients with specific VTE-investigation. ****, p-value <0.0001; 95%-CI, 95%-confidence interval; AUC, area under the ROC-curve; LR, likelihood ratio; PV, predictive value; ROC-curve, receiver-operating characteristic curve; VTE, venous thromboembolic events.
See this image and copyright information in PMC

Comment on

  • Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study.
    Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, Heinrich F, Mushumba H, Kniep I, Schröder AS, Burdelski C, de Heer G, Nierhaus A, Frings D, Pfefferle S, Becker H, Bredereke-Wiedling H, de Weerth A, Paschen HR, Sheikhzadeh-Eggers S, Stang A, Schmiedel S, Bokemeyer C, Addo MM, Aepfelbacher M, Püschel K, Kluge S. Wichmann D, et al. Ann Intern Med. 2020 Aug 18;173(4):268-277. doi: 10.7326/M20-2003. Epub 2020 May 6. Ann Intern Med. 2020. PMID: 32374815 Free PMC article.

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