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Review
. 2020 Sep;59(5):652-655.
doi: 10.1016/j.tjog.2020.07.004.

Fetal sex discordance

Álvaro López Soto  1 , Mar Bueno González  2 , Isabel Urbano Reyes  2 , Jose Luis Meseguer González  2 , M Ángeles Jódar Pérez  2 , Olivia García Izquierdo  2
Affiliations
Free article
Review

Fetal sex discordance

Álvaro López Soto et al. Taiwan J Obstet Gynecol. 2020 Sep.
Free article

Abstract

Fetal sex discordance is an entity that is becoming more frequent due to the expansion of the cfDNA for prenatal diagnosis. Its incidence can be estimated in 1/1500-2000 pregnancies, a frequency as high as that of some common chromosomopathies. The causes of this phenomenon are multiple and diverse, ranging from laboratory errors to important pathologies such as disorders of sexual differentiation. The management of a case of fetal sex discordance must be structured, starting with the review of the clinical history and the tests performed, and may require the performance of invasive tests to reach a diagnosis. Prevention through adequate pretest counseling and ultrasound confirmation can help to reduce its incidence.

Keywords: Fetal sex; Fetal sex discordance; NIPT; Prenatal testing; cfDNA.

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Conflict of interest statement

Declaration of Competing Interest The authors whose names are listed above certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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