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Comment
. 2020 Dec:92:102280.
doi: 10.1016/j.ceca.2020.102280. Epub 2020 Aug 28.

NCLX pumps up the heat

Trayambak Pathak  1 , Mohamed Trebak  2
Affiliations
Comment

NCLX pumps up the heat

Trayambak Pathak et al. Cell Calcium. 2020 Dec.

Abstract

Mitochondrial Ca2+ signaling is a well-appreciated regulator of cell metabolism and energy production. A major function of mitochondria in brown adipose tissue (BAT) is thermogenesis. Assali et al. offer new insights into how the mitochondrial Ca2+ extrusion mediator NCLX is crucial for BAT survival and thermogenesis.

Keywords: Brown adipose tissue; Mitochondrial Ca(2+) signaling; Mitochondrial Na(+)/Ca(2+) exchanger NCLX; Non-shivering thermogenesis.

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