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. 2020 Dec:117:111323.
doi: 10.1016/j.msec.2020.111323. Epub 2020 Aug 4.

Effects of cerium and tungsten substitution on antiviral and antibacterial properties of lanthanum molybdate

Takumi Matsumoto  1 , Kayano Sunada  2 , Takeshi Nagai  2 , Toshihiro Isobe  3 , Sachiko Matsushita  1 , Hitoshi Ishiguro  2 , Akira Nakajima  4
Affiliations

Effects of cerium and tungsten substitution on antiviral and antibacterial properties of lanthanum molybdate

Takumi Matsumoto et al. Mater Sci Eng C Mater Biol Appl. 2020 Dec.

Abstract

Powders of cerium (Ce)-substituted and tungsten (W)-substituted La2Mo2O9 (LMO) were prepared using polymerizable complex method. Their antiviral and antibacterial performances were then evaluated using bacteriophage Qβ, bacteriophage Φ6, Escherichia coli, and Staphylococcus aureus. The obtained powders, which were almost single-phase, exhibited both antiviral and antibacterial properties. Effects of dissolved ions on their antiviral activity against bacteriophage Qβ were remarkable. A certain contribution of direct contact to the powder surface was also inferred along with the dissolved ion effect for antiviral activity against bacteriophage Φ6. Dissolved ion effects and pH values suggest that both Mo and W are in the form of polyacids. Antiviral activity against bacteriophage Φ6 was improved by substituting Ce for La in LMO. Similarly to LMO, Ce-substituted LMO exhibited hydrophobicity. Inactivation of alkaline phosphatase enzyme proteins was inferred as one mechanism of the antiviral and antibacterial activities of the obtained powders.

Keywords: Antibacterial; Antiviral; Ce; La(2)Mo(2)O(9); W.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Unlabelled Image
Graphical abstract
Fig. 1
Fig. 1
XRD patterns of prepared powders.
Fig. 2
Fig. 2
SEM micrographs of prepared powders: (a) LMO, (b) LCMO, and (c) LMWO.
Fig. 3
Fig. 3
Results of antiviral activity against Qβ for prepared powders ((a) and (b)) and oxide reagents ((c) and (d)): (a) and (c), film adhesion method; and (b) and (d), dissolved ion contact method.
Fig. 4
Fig. 4
Results of antiviral activity against Φ6 for prepared powders ((a) and (b)) and oxide reagents ((c) and (d)): (a) and (c), film adhesion method; and (b) and (d), dissolved ion contact method.
Fig. 5
Fig. 5
Photographs of the change of plaque number for Φ6 by film adhesion method.
Fig. 6
Fig. 6
Results of antibacterial activity for powders and oxide reagents prepared using film adhesion method: (a) E. coli by prepared powders, (b) E. coli by oxide reagents, (c) S. aureus by prepared powders, and (d) S. aureus by oxide reagents.
Fig. 7
Fig. 7
ALP inactivation rate ((a) and (c)), and antibacterial activity rate against S. aureus ((b) and (d)) for prepared powders and oxide reagents.
Fig. 8
Fig. 8
Results of cytotoxicity tests for LMO, LCMO, and LMWO.
Fig. 9
Fig. 9
UV–Vis spectra of LMO and LCMO.
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