Multicenter Study

. 2021 Mar;40(3):812-819.

doi: 10.1016/j.clnu.2020.08.019. Epub 2020 Sep 5.

Six-month outcomes after individualized nutritional support during the hospital stay in medical patients at nutritional risk: Secondary analysis of a prospective randomized trial

Nina Kaegi-Braun¹, Pascal Tribolet², Filomena Gomes³, Rebecca Fehr¹, Valerie Baechli¹, Martina Geiser¹, Manuela Deiss¹, Alexander Kutz¹, Thomas Bregenzer⁴, Claus Hoess⁵, Vojtech Pavlicek⁵, Sarah Schmid⁵, Stefan Bilz⁶, Sarah Sigrist⁶, Michael Brändle⁶, Carmen Benz⁶, Christoph Henzen⁷, Silvia Mattmann⁷, Robert Thomann⁸, Jonas Rutishauser⁹, Drahomir Aujesky¹⁰, Nicolas Rodondi¹¹, Jacques Donzé¹², Zeno Stanga¹³, Beat Mueller¹⁴, Philipp Schuetz¹⁵

Affiliations

¹ Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland.
² Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Department of Health Professions, Bern University of Applied Sciences, Bern, Switzerland.
³ Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; The New York Academy of Sciences, USA.
⁴ Internal Medicine, Spital Lachen, Switzerland.
⁵ Internal Medicine, Kantonsspital Münsterlingen, Switzerland.
⁶ Internal Medicine & Endocrinology/Diabetes, Kantonsspital St.Gallen, Switzerland.
⁷ Internal Medicine, Kantonsspital Luzern, Switzerland.
⁸ Internal Medicine, Bürgerspital Solothurn, Switzerland.
⁹ Internal Medicine, Kantonsspital Baselland, Switzerland.
¹⁰ Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
¹¹ Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland; Institute of Primary Health Care (BIHAM), University of Bern, Switzerland.
¹² Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland; Division of General Internal Medicine, Brigham and Women's Hospital, Boston, MA, USA.
¹³ Division of Diabetology, Endocrinology, Nutritional Medicine & Metabolism, Inselspital, Bern University Hospital, University of Bern, Switzerland.
¹⁴ Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland.
¹⁵ Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland. Electronic address: schuetzph@gmail.com.

PMID: 32919819
DOI: 10.1016/j.clnu.2020.08.019

Free article

Multicenter Study

Six-month outcomes after individualized nutritional support during the hospital stay in medical patients at nutritional risk: Secondary analysis of a prospective randomized trial

Nina Kaegi-Braun et al. Clin Nutr. 2021 Mar.

Free article

. 2021 Mar;40(3):812-819.

doi: 10.1016/j.clnu.2020.08.019. Epub 2020 Sep 5.

Authors

Affiliations

¹ Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland.
² Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Department of Health Professions, Bern University of Applied Sciences, Bern, Switzerland.
³ Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; The New York Academy of Sciences, USA.
⁴ Internal Medicine, Spital Lachen, Switzerland.
⁵ Internal Medicine, Kantonsspital Münsterlingen, Switzerland.
⁶ Internal Medicine & Endocrinology/Diabetes, Kantonsspital St.Gallen, Switzerland.
⁷ Internal Medicine, Kantonsspital Luzern, Switzerland.
⁸ Internal Medicine, Bürgerspital Solothurn, Switzerland.
⁹ Internal Medicine, Kantonsspital Baselland, Switzerland.
¹⁰ Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
¹¹ Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland; Institute of Primary Health Care (BIHAM), University of Bern, Switzerland.
¹² Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland; Division of General Internal Medicine, Brigham and Women's Hospital, Boston, MA, USA.
¹³ Division of Diabetology, Endocrinology, Nutritional Medicine & Metabolism, Inselspital, Bern University Hospital, University of Bern, Switzerland.
¹⁴ Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland.
¹⁵ Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland. Electronic address: schuetzph@gmail.com.

PMID: 32919819
DOI: 10.1016/j.clnu.2020.08.019

Abstract

Background: Among medical inpatients at risk of malnutrition, the use of individualized nutritional support during the hospital stay was found to reduce complications and improve mortality at short-term. We evaluated clinical outcomes at 6-months follow-up.

Methods: We randomly assigned 2028 patients to receive protocol-guided individualized nutritional support to reach protein and energy goals (intervention group) or hospital food as usual (control group) during the hospital stay. The intervention was discontinued at hospital discharge and further nutritional support was based on the discretion of the treating team. We had complete follow-up information of 1995 patients (98%), which were included in the final analysis. The primary endpoint was all-cause mortality at 6-months. Prespecified secondary end points included non-elective hospital readmissions, functional outcome and quality of life.

Results: At 6-month, 231 of 994 (23.2%) intervention group patients had died compared to 246 of 999 (24.6%) control group patients, resulting in a hazard ratio for death of 0.90 (95%CI 0.76 to 1.08, p = 0.277). Compared to control patients, intervention group patients had similar rates of hospital readmission (27.3% vs. 27.6%, HR 1.00 (95%CI 0.84 to 1.18), p = 0.974), falls (11.2% vs. 10.9%, HR 0.96 (95%CI 0.72 to 1.27), p = 0.773) and similar quality of life and activities of daily living scores.

Interpretation: While individualized nutritional support during the hospital stay significantly reduced short-term mortality, there was no legacy effect on longer term outcomes. Future trials should investigate whether continuation of nutritional support after hospital discharge reduces the high malnutrition-associated mortality rates in this vulnerable patient population.

Trial registration: ClinicalTrials.gov number, NCT02517476.

Keywords: Clinical outcomes; Malnutrition; Nutritional support.

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Conflict of interest statement

Conflict of interest The study was investigator-initiated and supported by a grant from the Swiss National Science Foundation to P.Schuetz (SNSF Professorship, PP00P3_150531) and the Forschungsrat of the Kantonsspital Aarau (1410.000.058 and 1410.000.044). The institution of P.Schuetz has previously received unrestricted grant money unrelated to this project from Neste Health Science and Abbott Nutrition. The institution of Z.Stanga received speaking honoraria and research support from Neste Health Science, Abbott Nutrition and Fresenius Kabi. All other authors report no conflicts of interest.

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Six-month outcomes after individualized nutritional support during the hospital stay in medical patients at nutritional risk: Secondary analysis of a prospective randomized trial

Affiliations

Six-month outcomes after individualized nutritional support during the hospital stay in medical patients at nutritional risk: Secondary analysis of a prospective randomized trial

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

Associated data

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical