Antibody-dependent enhancement of coronavirus

doi:10.1016/j.ijid.2020.09.015

Review

. 2020 Nov:100:483-489.

doi: 10.1016/j.ijid.2020.09.015. Epub 2020 Sep 11.

Antibody-dependent enhancement of coronavirus

Jieqi Wen¹, Yifan Cheng², Rongsong Ling³, Yarong Dai⁴, Boxuan Huang⁵, Wenjie Huang⁶, Siyan Zhang⁷, Yizhou Jiang⁸

Affiliations

¹ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: 1900391007@email.szu.edu.cn.
² Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: chengdiefan2017@email.szu.edu.cn.
³ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: 2017182010@email.szu.edu.cn.
⁴ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: daiyarong2019@email.szu.edu.cn.
⁵ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: huangboxuan2017@email.szu.edu.cn.
⁶ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: 2017222014@email.szu.edu.cn.
⁷ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: zhangsiyan2016@email.szu.edu.cn.
⁸ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: jiangyz@szu.edu.cn.

PMID: 32920233
PMCID: PMC7483033
DOI: 10.1016/j.ijid.2020.09.015

Review

Antibody-dependent enhancement of coronavirus

Jieqi Wen et al. Int J Infect Dis. 2020 Nov.

. 2020 Nov:100:483-489.

doi: 10.1016/j.ijid.2020.09.015. Epub 2020 Sep 11.

Authors

Jieqi Wen¹, Yifan Cheng², Rongsong Ling³, Yarong Dai⁴, Boxuan Huang⁵, Wenjie Huang⁶, Siyan Zhang⁷, Yizhou Jiang⁸

Affiliations

¹ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: 1900391007@email.szu.edu.cn.
² Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: chengdiefan2017@email.szu.edu.cn.
³ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: 2017182010@email.szu.edu.cn.
⁴ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: daiyarong2019@email.szu.edu.cn.
⁵ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: huangboxuan2017@email.szu.edu.cn.
⁶ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: 2017222014@email.szu.edu.cn.
⁷ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: zhangsiyan2016@email.szu.edu.cn.
⁸ Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: jiangyz@szu.edu.cn.

PMID: 32920233
PMCID: PMC7483033
DOI: 10.1016/j.ijid.2020.09.015

Abstract

Antibody-dependent enhancement (ADE) exists in several kinds of virus. It has a negative influence on antibody therapy for viral infection. This effect was first identified in dengue virus and has since also been described for coronavirus. To date, the rapid spread of the newly emerged coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has affected over 3.8 million people across the globe. The novel coronavirus poses a great challenge and has caused a wave of panic. In this review, antibody-dependent enhancements in dengue virus and two kinds of coronavirus are summarized. Possible solutions for the effects are reported. We also speculate that ADE may exist in SARS-CoV-2.

Keywords: Antibody-dependent enhancement (ADE); Coronavirus disease 2019 (COVID-19); Middle East respiratory syndrome coronavirus (MERS-CoV); Severe acute respiratory syndrome coronavirus (SARS-CoV); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Figures

**Figure 1**
Mechanisms of antibody-dependent enhancement.

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References

1. Chan K.R., Zhang S.L.-X., Tan H.C., Chan Y.K., Chow A., Lim A.P.C., et al. Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection. Proc Natl Acad Sci USA. 2011;108:12479–12484. - PMC - PubMed
1. Chan J.F.-W., Zhang A.J., Yuan S., Poon V.K.-M., Chan C.C.-S., Lee A.C.-Y., et al. Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. Clin Infect Dis. 2020 doi: 10.1093/cid/ciaa325. pii: ciaa325. - DOI - PMC - PubMed
1. de Alwis R., Chen S., Gan E.S., Ooi E.E. Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development. EBioMedicine. 2020;55 doi: 10.1016/j.ebiom.2020.102768. - DOI - PMC - PubMed
1. Du L., Zhao G., Yang Y., Qiu H., Wang L., Kou Z., et al. A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein. J Virol. 2014;88:7045–7053. - PMC - PubMed
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[1] Chan K.R., Zhang S.L.-X., Tan H.C., Chan Y.K., Chow A., Lim A.P.C., et al. Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection. Proc Natl Acad Sci USA. 2011;108:12479–12484. - PMC - PubMed

[2] Chan K.R., Zhang S.L.-X., Tan H.C., Chan Y.K., Chow A., Lim A.P.C., et al. Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection. Proc Natl Acad Sci USA. 2011;108:12479–12484. - PMC - PubMed

[3] Chan J.F.-W., Zhang A.J., Yuan S., Poon V.K.-M., Chan C.C.-S., Lee A.C.-Y., et al. Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. Clin Infect Dis. 2020 doi: 10.1093/cid/ciaa325. pii: ciaa325. - DOI - PMC - PubMed

[4] Chan J.F.-W., Zhang A.J., Yuan S., Poon V.K.-M., Chan C.C.-S., Lee A.C.-Y., et al. Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. Clin Infect Dis. 2020 doi: 10.1093/cid/ciaa325. pii: ciaa325. - DOI - PMC - PubMed

[5] de Alwis R., Chen S., Gan E.S., Ooi E.E. Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development. EBioMedicine. 2020;55 doi: 10.1016/j.ebiom.2020.102768. - DOI - PMC - PubMed

[6] de Alwis R., Chen S., Gan E.S., Ooi E.E. Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development. EBioMedicine. 2020;55 doi: 10.1016/j.ebiom.2020.102768. - DOI - PMC - PubMed

[7] Du L., Zhao G., Yang Y., Qiu H., Wang L., Kou Z., et al. A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein. J Virol. 2014;88:7045–7053. - PMC - PubMed

[8] Du L., Zhao G., Yang Y., Qiu H., Wang L., Kou Z., et al. A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein. J Virol. 2014;88:7045–7053. - PMC - PubMed

[9] Duan K., Liu B., Li C., Zhang H., Yu T., Qu J., et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci USA. 2020;117(17):9490–9496. - PMC - PubMed

[10] Duan K., Liu B., Li C., Zhang H., Yu T., Qu J., et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci USA. 2020;117(17):9490–9496. - PMC - PubMed

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Antibody-dependent enhancement of coronavirus

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