Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Nov:100:483-489.
doi: 10.1016/j.ijid.2020.09.015. Epub 2020 Sep 11.

Antibody-dependent enhancement of coronavirus

Jieqi Wen  1 , Yifan Cheng  2 , Rongsong Ling  3 , Yarong Dai  4 , Boxuan Huang  5 , Wenjie Huang  6 , Siyan Zhang  7 , Yizhou Jiang  8
Affiliations
Review

Antibody-dependent enhancement of coronavirus

Jieqi Wen et al. Int J Infect Dis. 2020 Nov.

Abstract

Antibody-dependent enhancement (ADE) exists in several kinds of virus. It has a negative influence on antibody therapy for viral infection. This effect was first identified in dengue virus and has since also been described for coronavirus. To date, the rapid spread of the newly emerged coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has affected over 3.8 million people across the globe. The novel coronavirus poses a great challenge and has caused a wave of panic. In this review, antibody-dependent enhancements in dengue virus and two kinds of coronavirus are summarized. Possible solutions for the effects are reported. We also speculate that ADE may exist in SARS-CoV-2.

Keywords: Antibody-dependent enhancement (ADE); Coronavirus disease 2019 (COVID-19); Middle East respiratory syndrome coronavirus (MERS-CoV); Severe acute respiratory syndrome coronavirus (SARS-CoV); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mechanisms of antibody-dependent enhancement.
See this image and copyright information in PMC

References

    1. Chan K.R., Zhang S.L.-X., Tan H.C., Chan Y.K., Chow A., Lim A.P.C., et al. Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection. Proc Natl Acad Sci USA. 2011;108:12479–12484. - PMC - PubMed
    1. Chan J.F.-W., Zhang A.J., Yuan S., Poon V.K.-M., Chan C.C.-S., Lee A.C.-Y., et al. Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. Clin Infect Dis. 2020 doi: 10.1093/cid/ciaa325. pii: ciaa325. - DOI - PMC - PubMed
    1. de Alwis R., Chen S., Gan E.S., Ooi E.E. Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development. EBioMedicine. 2020;55 doi: 10.1016/j.ebiom.2020.102768. - DOI - PMC - PubMed
    1. Du L., Zhao G., Yang Y., Qiu H., Wang L., Kou Z., et al. A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein. J Virol. 2014;88:7045–7053. - PMC - PubMed
    1. Duan K., Liu B., Li C., Zhang H., Yu T., Qu J., et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci USA. 2020;117(17):9490–9496. - PMC - PubMed

MeSH terms