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. 2020 Dec:136:155264.
doi: 10.1016/j.cyto.2020.155264. Epub 2020 Sep 10.

Altered serum profile of the interleukin-22 system in inflammatory bowel disease

Ryosuke Sakemi  1 , Keiichi Mitsuyama  2 , Masaru Morita  3 , Shinichiro Yoshioka  3 , Kotaro Kuwaki  3 , Hidenori Tokuyasu  3 , Shuhei Fukunaga  3 , Atsushi Mori  3 , Toshihiro Araki  3 , Tetsuhiro Yoshimura  3 , Hiroshi Yamasaki  3 , Kozo Tsuruta  3 , Taku Morita  3 , Sayo Yamasaki  3 , Atsushi Mizoguchi  4 , Suketo Sou  1 , Takuji Torimura  3
Affiliations

Altered serum profile of the interleukin-22 system in inflammatory bowel disease

Ryosuke Sakemi et al. Cytokine. 2020 Dec.

Abstract

Background and aim: Interleukin-22 (IL-22), plays a vital role in the mucosal repair of inflammatory bowel disease (IBD). Serum levels of IL-22 and IL-22 binding protein (IL-22BP), a soluble inhibitory IL-22 receptor, were measured in patients with IBD to investigate the profile of IL-22 in the systemic circulation.

Methods: Blood samples from 92 healthy subjects, 98 patients with ulcerative colitis (UC), and 105 patients with Crohn's disease (CD) were analyzed for serum levels of IL-22, IL-22BP, human β-defensin 2 (hBD-2), and serum inflammatory parameters. Disease activity was assessed by the partial Mayo score and Harvey-Bradshaw index for UC and CD, respectively.

Results: Serum IL-22 level was lower in UC (P < 0.001) and CD (P < 0.001) vs control and its decrease was more pronounced in CD than in UC (P = 0.019). Serum IL-22BP level was lower in UC (P < 0.001) and CD (P < 0.001) vs control and correlated with inflammatory parameters (albumin and C-reactive protein (CRP) in UC; hemoglobin, albumin, and CRP in CD). Serum IL-22/IL-22BP ratios were higher in UC (P = 0.009) vs control and correlated with inflammatory parameters (albumin and CRP). Serum hBD-2 level was higher only in CD (P = 0.015) but did not correlate with serum IL-22 levels, IL-22BP levels, IL-22/IL-22BP ratios, or inflammatory parameters.

Conclusions: Dysregulation of the IL-22 system in the blood may play a role in the pathogenesis of IBD. Further studies are needed to understand the pathogenic and clinical significance of the blood IL-22 system in IBD.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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