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Observational Study
. 2020 Aug 27;91(3):e2020062.
doi: 10.23750/abm.v91i3.10373.

Covid-19 and the role of smoking: the protocol of the multicentric prospective study COSMO-IT (COvid19 and SMOking in ITaly)

Maria Sofia Cattaruzza  1 , Giuseppe Gorini  2 , Cristina Bosetti  3 , Roberto Boffi  4 , Alessandra Lugo  5 , Chiara Veronese  6 , Giulia Carreras  7 , Claudia Santucci  8 , Chiara Stival  9 , Roberta Pacifici  10 , Vincenzo Zagà  11 , Silvano Gallus  12 , Federico Giulietti  13 , Riccardo Sarzani  14 , Francesco Spannella  15 , Mario Del Donno  16 , Stefania Tartaglione  17 , Giuseppina Marrazzo  18 , Girolamo Pelaia  19 , Vincenzo D'Agosto  20 , Alice Berti  21 , Fabio Voller  22 , Salvatore Cardellicchio  23 , Chiara Cresci  24 , Maria Pia Foschino Barbaro  25 , Raffaele De Palma  26 , Simone Negrini  27 , Vera Sicbaldi  28 , Antonella Serafini  29 , Mario Bisconti  30 , Leonida Refolo  31 , Giovanni Landoni  32 , Patrizia Rovere  33 , Giulia Veronesi  34 , Paola Faverio  35 , Werner Garavello  36 , Alberto Pesci  37 , Raffaella Giacobbe  38 , Paola Martucci  39 , Roberto Parrella  40 , Francesco Scarano  41 , Marina Aiello  42 , Alfredo Chetta  43 , Cosimo Franco  44 , Angelo Mangia  45 , Laura Carrozzi  46 , Fabrizio Maggi  47 , Fabio Monzani  48 , Francesco Pistelli  49 , Patrizia Russo  50 , Antonio Sanna  51 , Filippo Maria Barreca  52 , Valentina Conti  53 , Enrico Rossi  54 , Mei Ruli  55 , Silvana Ruli  56 , Shokoofe Eslami Varzaneh  57 , Rosastella Principe  58 , Simone Guerrini  59 , Alfredo Sebastiani  60 , Giovanni Galluccio  61 , Aldo Pezzuto  62 , Alberto Ricci  63 , Elena Casali  64 , Claudio Mastroianni  65 , Pietro Pirina  66 , Francesca Polo  67 , Fabio Beatrice  68 , Micaela Romagnoli  69 , Massimo Baraldo  70 , Pier Giorgio Cojutti  71 , Carlo Tascini  72 , Davide Pecori  73 , Elena Graziano  74 , Biagio Tinghino  75
Affiliations
Observational Study

Covid-19 and the role of smoking: the protocol of the multicentric prospective study COSMO-IT (COvid19 and SMOking in ITaly)

Maria Sofia Cattaruzza et al. Acta Biomed. .

Abstract

The emergency caused by Covid-19 pandemic raised interest in studying lifestyles and comorbidities as important determinants of poor Covid-19 prognosis. Data on tobacco smoking, alcohol consumption and obesity are still limited, while no data are available on the role of e-cigarettes and heated tobacco products (HTP). To clarify the role of tobacco smoking and other lifestyle habits on COVID-19 severity and progression, we designed a longitudinal observational study titled COvid19 and SMOking in ITaly (COSMO-IT). About 30 Italian hospitals in North, Centre and South of Italy joined the study. Its main aims are: 1) to quantify the role of tobacco smoking and smoking cessation on the severity and progression of COVID-19 in hospitalized patients; 2) to compare smoking prevalence and severity of the disease in relation to smoking in hospitalized COVID-19 patients versus patients treated at home; 3) to quantify the association between other lifestyle factors, such as e-cigarette and HTP use, alcohol and obesity and the risk of unfavourable COVID-19 outcomes. Socio-demographic, lifestyle and medical history information will be gathered for around 3000 hospitalized and 700-1000 home-isolated, laboratory-confirmed, COVID-19 patients. Given the current absence of a vaccine against SARS-COV-2 and the lack of a specific treatment for -COVID-19, prevention strategies are of extreme importance. This project, designed to highly contribute to the international scientific debate on the role of avoidable lifestyle habits on COVID-19 severity, will provide valuable epidemiological data in order to support important recommendations to prevent COVID-19 incidence, progression and mortality.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article.

APPENDIX: The COSMO-IT Investigators

Ancona, Ospedali Riuniti di Torrette di Ancona (Federico Giulietti, Riccardo Sarzani, Francesco Spannella)

Benevento, AORN “S.Pio”- P.O. “G.Rummo” (Mario Del Donno, Stefania Tartaglione)

Catanzaro, Policlinico Universitario Magna Graecia, AO Mater Domini (Giuseppina Marrazzo, Girolamo Pelaia)

Eboli (SA), Ospedale Eboli (Vincenzo D’Agosto)

Firenze, ARS Toscana (Alice Berti, Fabio Voller)

Firenze, Azienda Ospedaliera Universitaria Careggi (Salvatore Cardellicchio, Chiara Cresci)

Firenze, Istituto per lo Studio, la Prevenzione, e la Rete Oncologica (Giulia Carreras, Giuseppe Gorini)

Foggia, Policlinico Riuniti (Maria Pia Foschino Barbaro)

Genova, Policlinico S. Martino (Raffaele De Palma, Simone Negrini, Vera Sicbaldi)

Imperia, Ospedale di Imperia, ASL 1 Imperiese (Antonella Serafini)

Lecce, Ospedale Vito Fazzi (Mario Bisconti, Leonida Refolo)

Milano, Fondazione IRCCS Istituto Nazionale dei Tumori (Roberto Boffi, Chiara Veronese)

Milano, Istituto di Ricerche Farmacologiche Mario Negri IRCCS (Cristina Bosetti, Silvano Gallus, Alessandra Lugo, Claudia Santucci, Chiara Stival)

Milano, Ospedale San Raffaele (Giovanni Landoni, Patrizia Rovere, Giulia Veronesi)

Monza, Ospedale San Gerardo (Paola Faverio, Werner Garavello, Alberto Pesci)

Napoli, A.O.R.N. A. Cardarelli (Raffaella Giacobbe, Paola Martucci)

Napoli, Ospedale Domenico Cotugno (Roberto Parrella, Francesco Scarano)

Parma, Azienda Ospedaliero Universitaria di Parma (Marina Aiello, Alfredo Chetta)

Piacenza, Ospedale Guglielmo da Saliceto (Cosimo Franco, Angelo Mangia)

Pisa, Azienda Ospedaliero-Universitaria Pisana (Laura Carrozzi, Fabrizio Maggi, Fabio Monzani, Francesco Pistelli, Patrizia Russo)

Pistoia, Ospedale San Jacopo, Azienda USL Toscana Centro (Antonio Sanna)

Reggio Calabria, Grande Ospedale Metropolitano (Filippo Maria Barreca)

Repubblica di San Marino, Ospedale di Stato (Valentina Conti, Enrico Rossi, Mei Ruli, Silvana Ruli)

Rieti, Ospedale S. Camillo De Lellis (Shokoofe Eslami Varzaneh)

Roma, Istituto Superiore di Sanità (Roberta Pacifici)

Roma, Azienda Ospedaliera San Camillo Forlanini (Rosastella Principe, Simone Guerrini, Alfredo Sebastiani, Giovanni Galluccio)

Roma, Azienda Ospedaliero-Universitaria Sant’Andrea (Aldo Pezzuto, Alberto Ricci)

Roma, Azienda Ospedaliero-Universitaria Policlinico Umberto I (Elena Casali, Claudio Mastroianni)

Roma, La Sapienza Università di Roma (Maria Sofia Cattaruzza)

Sassari, Azienda Ospedaliero Universitaria di Sassari (Pietro Pirina, Francesca Polo)

SITAB Società Italiana di Tabaccologia, Italy (Vincenzo Zagà)

Torino, Ospedale San Giovanni Bosco, ASL Città di Torino (Fabio Beatrice)

Treviso, Ospedale Cà Foncello, ULSS 2 (Micaela Romagnoli)

Udine, Azienza Sanitaria Universitaria Friuli Centrale (Massimo Baraldo, Pier Giorgio Cojutti, Elena Graziano, Davide Pecori, Carlo Tascini)

Vimercate (MB), ASST Vimercate (Biagio Tinghino)

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