Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Sep 7;91(3):e2020035.
doi: 10.23750/abm.v91i3.10391.

Sars-CoV-2 infection in patients with cystic fibrosis. An overview

Valentina Fainardi  1 , Francesco Longo  2 , Alfredo Chetta  3 , Susanna Esposito  1 , Giovanna Pisi  1
Affiliations
Review

Sars-CoV-2 infection in patients with cystic fibrosis. An overview

Valentina Fainardi et al. Acta Biomed. .

Abstract

The novel coronavirus SARS-CoV-2 was first identified in China in December 2019 and has since spread worldwide. People with Cystic Fibrosis (CF) have reduced survival mainly because of respiratory failure due to chronic pulmonary infections. Therefore, CF patients should be considered to have an increased risk of developing severe manifestations in case of SARS-CoV-2 infection. Surprisingly, the results of recent studies concerning SARS-CoV-2 infection in patients with CF show that in these patients the infection rate was lower than that of the general population. Various factors have been considered to explain a possible protective effect of CF against SARS-CoV-2 infection.

PubMed Disclaimer

Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

References

    1. Guan W, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382:1708–1720. - PMC - PubMed
    1. World Health Organization. WHO Director-General’s opening remarks at the media briefing on COVID-19 -11 March 2020. WHO. https://www.who.int/dg/speeches/detail/who-director-general-s-openingrem... .
    1. Fung SY, et al. A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses, Emerging Microbes & Infections. 2020;9:558–570. - PMC - PubMed
    1. Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods. Mol.Biol. >2015;1282:1–23. - PMC - PubMed
    1. Hoffmann , et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181:271–280. - PMC - PubMed