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Observational Study
. 2020 Aug 27;17(15):2306-2311.
doi: 10.7150/ijms.47000. eCollection 2020.

Study of weight and body mass index on graft loss after transplant over 5 years of evolution

Antonio Liñán González  1 , Raquel García Pérez  1 , Juan Bravo Soto  2 , Rafael Fernández Castillo  1
Affiliations
Observational Study

Study of weight and body mass index on graft loss after transplant over 5 years of evolution

Antonio Liñán González et al. Int J Med Sci. .

Abstract

Patients frequently experience a weight gain after organ transplantation. This increase in weight is the result of multiple factors, and is usually intensified by glucocorticoids and immunosuppressive drugs. It can also delay graft function and cause serious health problems. The objective of this study was to study the obesity as well as its causes and consequences in kidney transplant patients. The sample population consisted of 282 renal transplant patients, 170 men and 112 women, 18-74 years of age, who were monitored over a period of five years. For the purposes of our research, the patients were divided into two groups: (1) normal weight 18.5 ≤ BMI <25; (2) overweight 25 ≤ BMI ≤30. The association between BMI as an independent variable and graft survival was determined by means of a Cox regression analysis. Overweight patients were characterized by a higher comorbidity prevalence. In the Cox multivariate analysis, the initial BMI, evaluated as a continuous variable continued to be an independent predictor of delayed graft function and chronic nephropathy. This study evaluated the BMI as a continuous value instead of a categorical value. In conclusion, our results suggest that an increase in BMI without categorical variation can be an independent risk factor for graft loss. Consequently, obesity prevention for renal transplant patients should include dietary counseling and management, moderate physical activity, and steroid minimization.

Keywords: Anthropometry; BMI; Graft Loss; Kidney Transplant; Obesity; Overweight.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Evolution of the mean annual values of the weight in the simple population. As can be observed, these mean values of weight significantly increased from the first to the fifth year after transplant.
Figure 2
Figure 2
Evolution of the mean annual values of the Body Mass Index in the simple population. As can be observed, these mean values of BMI significantly increased from the first to the fifth year after transplant.
See this image and copyright information in PMC

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