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Case Reports
. 2020 Aug 9:22:e00921.
doi: 10.1016/j.idcr.2020.e00921. eCollection 2020.

Extraintestinal Clostridioides difficile infection

Zhao Hai  1 , Lei Peng Zhen  2 , Ma Juan  1 , Yang Fan  3 , Cang Jin Rong  1 , Liang Jing Yao  4 , Zhang Li Xia  1
Affiliations
Case Reports

Extraintestinal Clostridioides difficile infection

Zhao Hai et al. IDCases. .

Abstract

Clostridioides (Clostridium) difficile is the major cause of healthcare antibiotic-associated diarrhoea. However, extra-intestinal manifestations of Clostridioides (Clostridium) difficile infection (CDI) (including bacteremia and tissue infection) are extremely rare. We report a case of extraintestinal CDI after surgery. The isolate of C. difficile was not the PCR ribotype 027. However, this isolate produced toxins A and B. The patient underwent a follow-up examination 30 days after discharge, which showed complete recovery. This case report adds to existing knowledge of CDI.

Keywords: Clostridioides (clostridium) tissue infection infectious control.

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Conflict of interest statement

None to declare.

Figures

Fig. 1
Fig. 1
The blood culture revealed a Gram-positive bacillus.
Fig. 2
Fig. 2
X-ray examination of this patient. It is shown that comminuted fracture of the middle segment of the right tibia, oblique fracture of the upper segment of the right fibula.
Fig. 3
Fig. 3
The wound secretion was cultured on chromID C. difficile agar (CDIF) medium (Biomerieux® diagnostics, France) in anaerobic conditions (86% N2, 7% H2 and 7% CO2) at 37 °C for detecting C. difficile. After 24 hours, some blank colonies with entire edges formed on the agar media after 24 h.
See this image and copyright information in PMC

References

    1. Spigaglia P. Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection. Ther Adv Infect Dis. 2016;3(1):23–42. - PMC - PubMed
    1. Leffler D.A., Lamont J.T. Clostridium difficile infection. N Engl J Med. 2015;372(16):1539–1548. - PubMed
    1. Munson E., Rodriguez S., Riederer N. Outcome of electronic order alert intervention relative to toxigenic Clostridium difficile PCR analysis and hospital-onset C difficile infection in a multihospital health care system. Am J Clin Pathol. 2019;151(6):622–627. - PubMed
    1. Czepiel J., Dróżdż M., Pituch H. Clostridium difficile infection: review. Eur J Clin Microbiol Infect Dis. 2019 - PMC - PubMed
    1. Abreu Y., Abreu A.T., Velarde-Ruiz Velasco J.A., Zavala-Solares M.R. Consensus on the prevention, diagnosis, and treatment of Clostridium difficile infection. Rev Gastroenterol Mex. 2019 - PubMed

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