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Review
. 2020 Apr:32:149-155.
doi: 10.1016/j.cofs.2020.08.004. Epub 2020 Sep 9.

Potential use of polyphenols in the battle against COVID-19

Ines L Paraiso  1   2 , Johana S Revel  3 , Jan F Stevens  1   2
Affiliations
Review

Potential use of polyphenols in the battle against COVID-19

Ines L Paraiso et al. Curr Opin Food Sci. 2020 Apr.

Abstract

The coronavirus disease 2019 (COVID-19) is a public health emergency of international concern. The rising number of cases of this highly transmissible infection has stressed the urgent need to find a potent drug. Although repurposing of known drugs currently provides an accelerated route to approval, there is no satisfactory treatment. Polyphenols, a major class of bioactive compounds in nature, are known for their antiviral activity and pleiotropic effects. The aim of this review is to assess the effects of polyphenols on COVID-19 drug targets as well as to provide a perspective on the possibility to use polyphenols in the development of natural approaches against this viral disease.

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Figures

None
Graphical abstract
Figure 1
Figure 1
Effect of polyphenols on different steps of the SARS-CoV-2 life cycle. Polyphenols potentially inhibit binding of SARS-CoV-2 spike protein to host-cell receptor ACE2, prevent viral entry into the host cell, and inhibit viral RNA replication and protein processing.
See this image and copyright information in PMC

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