Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar 28;1(1):H9-H15.
doi: 10.1530/VB-19-0006. eCollection 2019.

Therapeutic vascular growth in the heart

Ebba Brakenhielm  1 , Vincent Richard  1
Affiliations
Review

Therapeutic vascular growth in the heart

Ebba Brakenhielm et al. Vasc Biol. .

Abstract

Despite tremendous efforts in preclinical research over the last decades, the clinical translation of therapeutic angiogenesis to grow stable and functional blood vessels in patients with ischemic diseases continues to prove challenging. In this mini review, we briefly present the current main approaches applied to improve pro-angiogenic therapies. Specific examples from research on therapeutic cardiac angiogenesis and arteriogenesis will be discussed, and finally some suggestions for future therapeutic developments will be presented.

Keywords: angiogenesis; biopolymers; endothelial dysfunction; exosomes; gene therapy; growth factor combinations; heart failure; ischemia; lymphangiogenesis; myocardial infarction; perfusion.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this review.

Figures

Figure 1
Figure 1
Combinatorial vascular approaches. Upper panel: Intermingled vascular networks including capillaries (podocalyxin+), arteries and arterioles (α-smooth muscle actin+) and lymphatics (LYVE1+) in healthy rodent hearts visualized by light sheet imaging of whole-mount stained clarified samples. Lower panel: Examples of additive or synergistic growth factor combinations (indicated by solid lines) evaluated for therapeutic angiogenesis, arteriogenesis or lymphangiogenesis using gene or protein therapy (20, 23, 24, 37, 38, 39, 60, 61).
Figure 2
Figure 2
Challenges for therapeutic angiogenesis. In order to grow stable and functional blood vessels in patients with ischemic diseases, several important therapeutic challenges remain, including both basic science and clinical questions (What cocktail of angiogenic factors must be applied to stimulate both capillary and arteriolar growth? How can therapies overcome potential inherent angiogenic resistance in patients?) as well as technical hurdles (How to control spatiotemporally the release of multiple angiogenic factors?). This may require devising multimodal solutions, based on combinations of different aspects of gene, protein and cell/cell-free exosome therapy, for efficient and safe targeting of angiogenic therapies in patients.
See this image and copyright information in PMC

References

    1. Cao Y, Arbiser J, D’Amato RJ, D’Amore PA, Ingber DE, Kerbel R, Klagsbrun M, Lim S, Moses MA, Zetter B, et al Forty-year journey of angiogenesis translational research. Science Translational Medicine 2011. 3 114rv3–114rv3. (10.1126/scitranslmed.3003149) - DOI - PMC - PubMed
    1. Kant RJ, Coulombe KLK. Integrated approaches to spatiotemporally directing angiogenesis in host and engineered tissues. Acta Biomaterialia 2018. 69 42–62. (10.1016/j.actbio.2018.01.017) - DOI - PMC - PubMed
    1. Carrabba M, Madeddu P. Current strategies for the manufacture of small size tissue engineering vascular grafts. Frontiers in Bioengineering and Biotechnology 2018. 6 41 (10.3389/fbioe.2018.00041) - DOI - PMC - PubMed
    1. Halcox JPJ, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, Nour KR, Quyyumi AA. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002. 106 653–658. (10.1161/01.CIR.0000025404.78001.D8) - DOI - PubMed
    1. Eelen G, de Zeeuw P, Simons M, Carmeliet P. Endothelial cell metabolism in normal and diseased vasculature. Circulation Research 2015. 116 1231–1244. (10.1161/CIRCRESAHA.116.302855) - DOI - PMC - PubMed

LinkOut - more resources