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. 2020 Nov;9(21):7964-7978.
doi: 10.1002/cam4.3428. Epub 2020 Sep 13.

Sarcopenia and adverse health-related outcomes: An umbrella review of meta-analyses of observational studies

Lin Xia  1 , Rui Zhao  1 , Qianyi Wan  1 , Yutao Wu  2 , Yong Zhou  1 , Yong Wang  1 , Yaping Cui  1 , Xiaoding Shen  1 , Xiaoting Wu  1
Affiliations

Sarcopenia and adverse health-related outcomes: An umbrella review of meta-analyses of observational studies

Lin Xia et al. Cancer Med. 2020 Nov.

Abstract

Objective: The purpose of this umbrella review was to assess the associations between sarcopenia and adverse health-related outcomes.

Design: An umbrella review of meta-analyses of observational studies.

Setting and participants: Patients with sarcopenia and controls without sarcopenia were included.

Measures: The PubMed, Web of Science and Embase were searched for relevant systematic review and meta-analysis. AMSTAR and GRADE system were used for methodological quality and evidence quality assessments, respectively.

Results: Totally 54 outcomes extracted from 30 meta-analyses were analyzed. Twenty out of 21 prognostic outcomes indicated that sarcopenia was significantly associated with poorer prognosis of gastric cancer, hepatocellular cancer, urothelial cancer, head and neck cancer, hematological malignancy, pancreatic cancer, breast cancer, colorectal cancer, lung cancer, esophageal cancer, and ovarian cancer. Besides, 10 out of 16 postoperative outcomes suggested that sarcopenia significantly increased the risk of multiple postoperative complications and prolonged the length of hospitalization of patients with digestive cancer. In age-related outcomes, sarcopenia significantly increased the risk of dysphagia, cognitive impairment, fractures, falls, hospitalization, and all-cause mortality of elderly populations. Moreover, sarcopenia was also associated with higher level of albuminuria, risk of depression, and several metabolic diseases.

Conclusions and implications: Sarcopenia significantly affected a wide range of adverse health-related outcomes, particularly in patients of tumor and elderly populations. Because evidences of most outcomes were rated as "low" and "very low," more prospective cohort studies are required in the future.

Keywords: AMSTAR; GRADE; health-related outcomes; sarcopenia; umbrella review.

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Conflict of interest statement

There was no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Forest plot of prognostic outcomes of tumor having significant associations with sarcopenia
FIGURE 2
FIGURE 2
Forest plot of postoperative outcomes having significant associations with sarcopenia
FIGURE 3
FIGURE 3
Forest plot of age‐related outcomes having significant associations with sarcopenia
FIGURE 4
FIGURE 4
Forest plot of metabolic outcomes having significant associations with sarcopenia
See this image and copyright information in PMC

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