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Observational Study
. 2020 Nov;272(5):807-813.
doi: 10.1097/SLA.0000000000004341.

Incidence and Grading of Complications After Gastrectomy for Cancer Using the GASTRODATA Registry: A European Retrospective Observational Study

Gian Luca Baiocchi  1 , Simone Giacopuzzi  2 , Daniel Reim  3 , Guillaume Piessen  4 , Paulo Matos da Costa  5 , John V Reynolds  6 , Hans-Joachim Meyer  7 , Paolo Morgagni  8 , Ines Gockel  9 , Lucio Lara Santos  10 , Lone Susanne Jensen  11 , Thomas Murphy  12 , Domenico D'Ugo  13 , Riccardo Rosati  14 , Uberto Fumagalli Romario  15 , Maurizio Degiuli  16 , Wojciech Kielan  17 , Stefan Mönig  18 , Piotr Kołodziejczyk  19 , Wojciech Polkowski  20 , Manuel Pera  21 , Paul M Schneider  22 , Bas Wijnhoven  23 , Wobbe O de Steur  24 , Suzanne S Gisbertz  25 , Henk Hartgrink  24 , Johanna W van Sandick  26 , Maristella Botticini  27 , Arnulf H Hölscher  28 , William Allum  29 , Giovanni De Manzoni  2
Affiliations
Observational Study

Incidence and Grading of Complications After Gastrectomy for Cancer Using the GASTRODATA Registry: A European Retrospective Observational Study

Gian Luca Baiocchi et al. Ann Surg. 2020 Nov.

Abstract

Objective: Utilizing a standardized dataset based on a newly developed list of 27 univocally defined complications, this study analyzed data to assess the incidence and grading of complications and evaluate outcomes associated with gastrectomy for cancer in Europe.

Summary background data: The absence of a standardized system for recording gastrectomy-associated complications makes it difficult to compare results from different hospitals and countries.

Methods: Using a secure online platform (www.gastrodata.org), referral centers for gastric cancer in 11 European countries belonging to the Gastrectomy Complications Consensus Group recorded clinical, oncological, and surgical data, and outcome measures at hospital discharge and at 30 and 90 days postoperatively. This retrospective observational study included all consecutive resections over a 2-year period.

Results: A total of 1349 gastrectomies performed between January 2017 and December 2018 were entered into the database. Neoadjuvant chemotherapy was administered to 577 patients (42.8%). Total (46.1%) and subtotal (46.4%) gastrectomy were the predominant resections. D2 or D2+ lymphadenectomy was performed in almost 80% of operations. The overall complications' incidence was 29.8%; 402 patients developed 625 complications, with the most frequent being nonsurgical infections (23%), anastomotic leak (9.8%), other postoperative abnormal fluid from drainage and/or abdominal collections (9.3%), pleural effusion (8.3%), postoperative bleeding (5.6%), and other major complications requiring invasive treatment (5.6%). The median Clavien-Dindo score and Comprehensive Complications Index were IIIa and 26.2, respectively. In-hospital, 30-day, and 90-day mortality were 3.2%, 3.6%, and 4.5%, respectively.

Conclusions: The use of a standardized platform to collect European data on perioperative complications revealed that gastrectomy for gastric cancer is still associated with heavy morbidity and mortality. Actions are needed to limit the incidence of, and to effectively treat, the most frequent and most lethal complications.

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References

    1. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136:E359–386.
    1. De Manzoni G, Marrelli D, Baiocchi GL, et al. The Italian Research Group for Gastric Cancer (GIRCG) guidelines for gastric cancer staging and treatment: 2015. Gastric Cancer 2017; 20:20–30.
    1. Baiocchi GL, D’Ugo D, Coit D, et al. Follow-up after gastrectomy for cancer. The Charter Scaligero Consensus Conference. Gastric Cancer 2016; 19:15–20.
    1. Marrelli D, Polom K, de Manzoni G, et al. Multimodal treatment of gastric cancer in the west: Where are we going? World J Gastroenterol 2015; 21:7954–7969.
    1. Sano T, Sasako M, Yamamoto S, et al. Gastric cancer surgery: morbidity and mortality results from a prospective randomized controlled trial comparing D2 and extended para-aortic lymphadenectomy—Japan Clinical Oncology Group study 9501. J Clin Oncol 2004; 22:2767–2773.

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