Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Oct;131(4):989-992.
doi: 10.1213/ANE.0000000000005140.

Human Leukocyte Antigen-DR Deficiency and Immunosuppression-Related End-Organ Failure in SARS-CoV2 Infection

Affiliations
Comment

Human Leukocyte Antigen-DR Deficiency and Immunosuppression-Related End-Organ Failure in SARS-CoV2 Infection

Jaroslaw W Zmijewski et al. Anesth Analg. 2020 Oct.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure.
Figure.
Reduced levels of HLA-DR are associated with the development of immunosuppression, high risk of secondary bacterial infections, and end-organ failure in intensive care unit patients with SARS-CoV2. ARDS indicates xxx; HLA-DR, human leukocyte antigen-DR; MФ, macrophages; PD-L1, programmed death 1 ligand; SARS-CoV2, severe acute respiratory syndrome coronavirus 2.

Comment on

Similar articles

Cited by

References

    1. Spinetti T, Hirzel C, Fux M, et al. Reduced monocytic HLA-DR expression indicates immunosuppression in critically ill COVID-19 patients. Anesth Analg. 2020. - PMC - PubMed
    1. Venet F, Tissot S, Debard AL, et al. Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: correlation with severity and secondary septic shock. Crit Care Med. 2007;35:1910–1917. - PubMed
    1. Pfortmueller CA, Meisel C, Fux M, Schefold JC. Assessment of immune organ dysfunction in critical illness: utility of innate immune response markers. Intensive Care Med Exp. 2017;5:49. - PMC - PubMed
    1. Venet F, Rimmelé T, Monneret G. Management of sepsis-induced immunosuppression. Crit Care Clin. 2018;34:97–106. - PubMed
    1. Volk HD, Thieme M, Heym S, et al. Alterations in function and phenotype of monocytes from patients with septic disease—predictive value and new therapeutic strategies. Behring Inst Mitt. 1991:208–215. - PubMed

Publication types